Ryks: new partners for Wnts in the developing and regenerating …
2009年12月10日 · Conserved Ryk transmembrane proteins, tyrosine kinase-related Wnt receptors, are important during neurogenesis, axon guidance and synaptogenesis. Here, we …
The non-canonical Wnt receptor Ryk regulates hematopoietic stem …
2016年11月24日 · We here investigate the role of the non-canonical Wnt receptor Ryk in hematopoiesis and lymphoid development. We show that there are dynamic changes in Ryk …
WNT/RYK signaling functions as an antiinflammatory modulator …
2022年6月7日 · Our results indicate that RYK signaling through β-catenin and Nuclear Factor kappa B (NF-κB) is part of a safeguard mechanism against mesenchymal cell death, …
The complex world of WNT receptor signalling - Nature
2012年11月15日 · WNT receptors and co-receptors are regulated intracellularly by phosphorylation, proteolytic processing and endocytosis. Endocytosis is a key mechanism, …
Mammalian Ryk Is a Wnt Coreceptor Required for Stimulation of …
2004年10月1日 · Here, we report that mammalian Ryk, unlike the Drosophila Ryk homolog Derailed, functions as a coreceptor along with Frizzled for Wnt ligands. Ryk also binds to …
Ryks: new partners for Wnts in the developing and ... - ScienceDirect
2010年2月1日 · Conserved Ryk transmembrane proteins, tyrosine kinase-related Wnt receptors, are important during neurogenesis, axon guidance and synaptogenesis. Here, we review the …
Ryk: A novel Wnt receptor regulating axon pathfinding
2006年1月1日 · The versatility and complexity of Wnt signaling has been further highlighted by the emergence of a novel family of Wnt receptors, the Ryk family. In mammals and flies, Ryk is a …
Cleavage of the Wnt Receptor Ryk Regulates Neuronal …
2008年11月11日 · Here, we show that Ryk is cleaved, permitting the intracellular C-terminal fragment of Ryk to translocate to the nucleus in response to Wnt3 stimulation. We also show …
The Wnt Receptor Ryk Reduces Neuronal and Cell Survival …
2014年6月24日 · The Wnt receptor Ryk is an evolutionary-conserved protein important during neuronal differentiation through several mechanisms, including γ-secretase cleavage and …
Non-canonical Wnt Signaling through Ryk Regulates the …
2019年9月4日 · Indeed, gain of function of Ryk intracellular domain signaling regulates SST and PV fate in a dose-dependent manner, suggesting that Ryk signaling acts in a graded fashion. …