SFRPs Are Biphasic Modulators of Wnt-Signaling-Elicited Cancer …
2019年8月6日 · SFRPs have been known to modulate the Wnt signaling pathway by directly binding with Wnt ligands to block the interaction between the Wnt and Frizzled receptor. …
Soluble Frizzled-related proteins promote exosome-mediated Wnt …
2024年3月1日 · Here, the authors show that Wnt heterodimerization with its carrier protein, sFRP2, enhances Wnt accumulation on the cell surface, leading to exosome-mediated Wnt re …
sFRPs: a declaration of (Wnt) independence - Nature Cell Biology
2008年12月14日 · Activation of the Wnt signal is antagonized by the secreted Frizzled-related proteins (sFRPs), the largest family of Wnt inhibitors, whose members share sequence …
Wnt/β-catenin 信号通路 - CSDN博客
经典 Wnt 通路，也称为 Wnt/β-catenin 通路，涉及 β-catenin 的核转位和通过 TCF/LEF 转录因子激活靶基因。 经典 Wnt 通路主要控制细胞增殖，而非经典 Wnt 通路调节细胞极性和迁移，两种 …
Wnt Signaling and sFRPs - R&D Systems
One mode of signaling pathway regulation occurs at the level of extracellular antagonists that interact with ligands and prevent signaling. The secreted Frizzled-related proteins (sFRP) were …
来看！为你翻译了这篇Cell综述，不再遗憾错过Wnt信号通路 - 知乎
2023年6月4日 · Wnt信号通路 是胚胎及器官发育的重要信号通路之一，参与调控机体内多种细胞的增殖、分化、极化、迁移及凋亡等过程。 Wnt信号通路根据是否依赖于 β-catenin 的转录活 …
Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway …
We investigated the function of the histone chaperone SSRP1 during cellular differentiation and demonstrate its essential function in specifically directing multipotent mesenchymal stem cell …
SSRP1 Promotes Lung Cancer Progression by Blocking the WNT …
2021年2月18日 · Silencing of SSRP1 by siRNA inhibited lung cancer proliferation, migration and invasion by blocking the WNT signaling pathway in vitro and vivo. We also verified SSRP1 …
分泌型卷曲相关蛋白家族在Wnt信号通路中的双向调节作用
分泌型卷曲相关蛋白（secreted frizzled-related proteins，sFRPs）是一种可溶性蛋白质，因其结构与Wnt信号的卷曲蛋白（frizzled，Fz）受体高度同源而被认为是一类Wnt通路拮抗剂。
【研究专题】细胞信号传导的关键角色—Wnt通路 - 知乎
Wnt通路 是一条重要的细胞信号传导通路，参与胚胎发育、细胞增殖、分化和组织稳态等过程。 它主要分为经典的 β-catenin 依赖性通路和非依赖性β-catenin通路。 经典β-catenin依赖性通 …