非经典 Wnt信号/ 钙通路 中，Wnt5通过与细胞膜上的Frizzled结合,激活 PLC,PLC促进钙离子的生成，钙离子进一步作用于 CAMKII,CaN,PKC-, 其中， CaN 通过 去磷酸化 作用于 NFAT …

WNT5A is a signaling molecule expressed embryonically during gastrulation in various developing body regions including the caudal mesoderm of the primitive streak, lateral mesoderm, cranial …

Wnt5a is a representative ligand that activates the β-catenin-independent pathways. Because the β-catenin-independent pathway includes multiple signalling cascades in addition to the planar …

Wnt/Ca2+通路，由Wnt5a和Wnt11激活. 这3条信号通路主要成分包括：分泌蛋白Wnt家族、跨膜受体 Frizzled家族 、CK1、Deshevelled、GSK3、APC、Axin、β-Catenin、以及转录因 …

Oct 11, 2023 · Wnt信号通路是一种复杂的信号转导系统，能够参与调控生物体内多种细胞命运决定、细胞增殖和分化等重要生物学过程。 以下是Wnt信号通路中的主要基因介绍。 Wnt信号通路 …

WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can also activate β-catenin signaling to relay its diverse cellular effects such as cell polarity, migration, …

Wnt 配体是一种分泌型糖蛋白，可结合 Frizzled (卷曲）受体，然后与 LRP5/6 一起在细胞表面形成一个更大的复合体。 卷曲受体被 ZNRF3 和 RNF43 泛素化，二者的活性可通过 R-spondin 结 …

Dec 25, 2024 · WNT5B (Wnt Family Member 5B) is a Protein Coding gene. Diseases associated with WNT5B include Type 1 Diabetes Mellitus 4 and Fibular Aplasia Or Hypoplasia, Femoral …

Jul 23, 2021 · WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B …

Jan 3, 2022 · Extracellular signals are mainly mediated by Wnt proteins, including Wnt3a, Wnt1, and Wnt5a. The cell membrane segment mainly contains the Wnt receptors Frizzled (specific …