2022年1月5日 · Cell information for WRO. Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Retrovirus-mediated herpes simplex virus thymidine kinase gene transduction renders human thyroid carcinoma cell lines sensitive to ganciclovir and radiation in vitro and in vivo. Endocrinology 138:4577-4583(1997)

In this study, we found that WRO cell line, which has a BRAFV600E mutation, is the most tumorigenic of the three human FTC cell lines tested. Activating mutations in BRAF , a 766-amino acid serine/threonine-specific protein kinase, have been detected in …

2012年11月15日 · The mutational status of six human thyroid cancer cell lines (WRO, FTC133, BCPAP, TPC1, K1, and 8505C) was in line with previously reported findings for 10 genes frequently mutated in thyroid cancer. However, the presence of a BRAF mutation (T1799A: V600E) in WRO questions the use of this cell line as a …

2024年12月7日 · (C) WRO cells were treated with cycloheximide (150 μM) to investigate JUP protein stability with circSSU72 knockdown. (D) Ubiquitination of JUP was determined by immunoprecipitation and western blot assays.

WRO cells were infected with adenovirus containing VDR cDNA (VDR-adv) or control adenovirus (control-adv). Cell proliferation was determined by BrdU incorporation (C) and colony formation assay (D) after overexpression of VDR in WRO cells.

The present study demonstrates that salidroside inhibits migration and invasion of WRO cells (a kind of poorly differentiated cancer cell line) significantly, which might be via suppressing JAK2-STAT3 signaling pathway.

IG20 knockdown renders WRO cells more susceptible to spontaneous, TRAIL-, and TNFalpha-induced apoptosis and thus demonstrates the prosurvival function of the IG20 gene in thyroid cancer. These observations, combined with overexpression of IG20 noted in thyroid tumor tissues, may suggest a potential …

2016年9月10日 · Upregulaion of miRNA-203 in WRO cells effectively reduced cell growth, G 2 /M arrest. Mechanistically, in the miRNA-203-mimics-treated groups, cell-cycle-related proteins cyclin B1 was up-regulated, while cyclin D1 was down-regulated.

2023年4月28日 · Piperlongumine modulated cellular autophagy via the ROS/Akt/mTOR/p70S6K pathway in human follicular thyroid cancer cells. WRO cells were incubated with control or piperlongumine, and (A) the activation of signaling pathways, including Akt, Erk, JNK, p38, and (B) mTOR, p70S6K, and LC3-II