Wyatt Erk is on Facebook. Join Facebook to connect with Wyatt Erk and others you may know. Facebook gives people the power to share and makes the world...

ERK进入细胞核后直接磷酸化转录因子Elk-1的多个位点，如Ser383 和 Ser389 等。 磷酸化后的Elk-1构象发生改变，与血清反应因子（SRF）的相互作用，形成高活性的转录因子复合物。

ERK是一种丝氨酸/苏氨酸蛋白激酶，是一种传递有丝分裂原信号的信号转导蛋白。 ERK通常位于细胞质中；在被激活后，ERK进入细胞核，调节转录因子活性和基因表达。

2015年8月31日 · We show that activation of overexpressed CaSR leads to activation of ERK1 and ERK2, and pharmacological inhibition of CaSR-dependent ERK1/ERK2 activation prevents CaSR-dependent axon growth.

In cell culture studies, 4-OI promotes endothelial cell proliferation and migration, mediated by Mitogen-Activated Protein Kinases (MAPK) signaling pathway activation, particularly through Extracellular Signal-Regulated Kinase (ERK) signaling. Inhibition of ERK blocks these beneficial effects on endothelial cells.

Explore the ERK pathway and its role in cell proliferation and survival. Click here to read more about this critical signaling pathway.

2020年8月3日 · 总结：Erk/MAPK 信号通过细胞自主和非自主机制调节 Wnt 信号通路在肠道发育过程中发挥关键作用。 雷帕霉素对 mTor 信号的抑制部分挽救了 Erk1/2 耗竭引起的肠道缺陷，并显着延长了突变小鼠的寿命。

2021年10月1日 · ERK激酶是MEK激酶的唯一下游靶点， 研究显示，靶向于ERK靶点的抑制剂能够有效阻断RAS-RAF-MEK-ERK信号通路，同时能够有效逆转由上游BRAF、MEK突变而导致的耐药。

2020年6月23日 · We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2. We then systematically discuss how ERK signalling regulates six...

CD40L reverse signaling increased phosphorylation and hence activation of proteins in the PKC, ERK, and JNK signaling pathways. Pharmacological activators and inhibitors of these pathways revealed that whereas activation of JNK inhibited growth, activation of PKC and ERK1/ERK2 enhanced growth.