Comparative genomic hybridization (CGH) is a molecular cytogenetic method for analysing copy number variations (CNVs) relative to ploidy level in the DNA of a test sample compared to a reference sample, without the need for culturing cells.

比较基因组杂交 （英語： Comparative genomic hybridization， CGH）是一种分子 细胞遗传学 方法，在不培养 细胞 的情况下，分析相对于参照样品，测试样品的DNA中 拷贝数变异 （英语：Copy-number variation） （CNV）的多倍性程度。 其目的是快速有效地比较两个来源的两组DNA样本，这两组DNA通常是密切相关的，因为两者在整个 染色体 或亚染色体区域（整个染色体的一部分）上都可能有获得或丢失。 该技术最初是为了评估实体瘤和正常组织的染色体互补 …

Comparative genomic hybridisation (CGH) is a technique that permits the detection of chromosomal copy number changes without the need for cell culturing. It provides a global overview of chromosomal gains and losses throughout the whole genome of a ...

这里主要介绍采用基因芯片的cgh，其原理是：先分别将肿瘤与正常细胞的基因组dna打碎，再利用双色荧光杂交的策略，对肿瘤细胞基因组dna片段进行红色荧光(cy5荧光素)标记

Array-CGH involves the comparison of a test to a reference genome using a microarray composed of target sequences with known chromosomal coordinates. The test and reference DNA samples are used as templates to generate two …

2011年6月10日 · X-linked congenital generalized hypertrichosis (CGH), an extremely rare condition characterized by universal overgrowth of terminal hair, was first mapped to chromosome Xq24-q27.1 in a Mexican family. However, the underlying genetic defect remains unknown.

cgh试剂盒是一个检测与染色体异常相关的dna拷贝数增加和减少的强大产品，能够帮助研究者们对遗传疾病、癌症和其他基因组畸变进行更深入的理解和研究。

X-linked congenital generalized hypertrichosis (CGH), an extremely rare condition characterized by universal overgrowth of terminal hair, was first mapped to chromosome Xq24-q27.1 in a Mexican family.

Here, we describe the production and validation of a full coverage X-array-CGH, which will allow for fast and easy screening of submicroscopic copy number alterations in XLMR patients with the aim to identify novel MR genes or mechanisms involved in a deranged cognitive development.

In the past two decades, comparative genomic hybridization (CGH) and array CGH have become indispensable tools in clinical diagnostics and toxicological risk assessment. Initially developed for the genome-wide screening of chromosomal imbalances, that is, copy-number variations in tumor cells, both CGH and array CGH have been employed in ...