XAF1 Gene - GeneCards | XAF1 Protein | XAF1 Antibody
2024年12月25日 · XAF1 (XIAP Associated Factor 1) is a Protein Coding gene. Diseases associated with XAF1 include Cataract 37 and Exocervical Carcinoma. Among its related …
XAF1 - Wikipedia
XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be …
XAF1 forms a positive feedback loop with IRF-1 to drive ... - Nature
2018年7月24日 · Collectively, this study identifies a novel mechanism of XAF1-mediated tumor suppression, uncovering XAF1 as a feedback coactivator of IRF-1 under stressful conditions.
XAF1 drives apoptotic switch of endoplasmic reticulum stress …
2022年7月28日 · Collectively this study uncovers an important role for XAF1 as a linchpin to govern the sensitivity to ER stress and the outcomes of UPR signaling, illuminating the …
XAF1 Protects Host against Emerging RNA Viruses by Stabilizing
2022年9月14日 · XAF1 stabilizes IRF1 protein by antagonizing the CHIP-mediated degradation of IRF1, thus inducing more antiviral IRF1 target genes, including DDX58, DDX60, MX1, and …
XAF1 promotes anti-RNA virus immune responses by regulating
2023年8月18日 · XAF1 deficiency led to an extensive decrease in chromatin accessibility at the promoter (≤1 kb) at 3 hours after VSV infection (fig. S7A). BST2, OAS2, DDX60, and RNASEL …
Identification of XAF1 as an endogenous AKT inhibitor - Cell Press
XAF1 (XIAP-associated factor) was first discovered as an XIAP binding protein by yeast two hybrid, and it strongly inhibits XIAP’s anti-caspase activity through direct interaction, …
XAF1 promotes anti-RNA virus immune responses by regulating
2023年8月18日 · XAF1-deficient mice were susceptible to RNA virus due to impaired induction of antiviral genes. Together, XAF1 acts as an epigenetic regulator that promotes the opening of …
XAF1 XIAP associated factor 1 [ (human)] - National Center for ...
2025年2月8日 · XAF1 overexpression inhibits the malignant progression and cisplatin resistance of NSCLC by activating endoplasmic reticulum stress. XAF1 promotes colorectal cancer …
XAF1 prevents hyperproduction of type I interferon upon viral …
2022年11月17日 · The XAF1‐XIAP‐KLHL22 axis functions as a major regulator that controls IRF7 protein abundance and helps to maintain a proper level of this protein. XAF1 has been shown …