Dec 25, 2024 · XAF1 (XIAP Associated Factor 1) is a Protein Coding gene. Diseases associated with XAF1 include Cataract 37 and Exocervical Carcinoma. Among its related pathways are Cytokine Signaling in Immune system and Antiviral mechanism by IFN-stimulated genes. An important paralog of this gene is TRAFD1.

XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer …

Jul 24, 2018 · Collectively, this study identifies a novel mechanism of XAF1-mediated tumor suppression, uncovering XAF1 as a feedback coactivator of IRF-1 under stressful conditions.

Jul 28, 2022 · Collectively this study uncovers an important role for XAF1 as a linchpin to govern the sensitivity to ER stress and the outcomes of UPR signaling, illuminating the mechanistic consequence of...

Sep 14, 2022 · XAF1 stabilizes IRF1 protein by antagonizing the CHIP-mediated degradation of IRF1, thus inducing more antiviral IRF1 target genes, including DDX58, DDX60, MX1, and OAS2. Our study has described a protective role of XAF1 in …

Aug 18, 2023 · XAF1 deficiency led to an extensive decrease in chromatin accessibility at the promoter (≤1 kb) at 3 hours after VSV infection (fig. S7A). BST2, OAS2, DDX60, and RNASEL encode important antiviral effectors transcriptionally regulated by IRF1. ARG2, IFIT1, CXCL10, and IL15 encode important antiviral effectors directed by IRF3.

XAF1 (XIAP-associated factor) was first discovered as an XIAP binding protein by yeast two hybrid, and it strongly inhibits XIAP’s anti-caspase activity through direct interaction, suggesting its role as a pro-apoptosis factor and tumor suppressor. 20 Lately, XAF1 was found to promote the ubiquitination and degradation of Survivin by forming ...

Aug 18, 2023 · XAF1-deficient mice were susceptible to RNA virus due to impaired induction of antiviral genes. Together, XAF1 acts as an epigenetic regulator that promotes the opening of chromatin and activation of antiviral immunity by targeting TRIM28 during infection.

Feb 8, 2025 · XAF1 overexpression inhibits the malignant progression and cisplatin resistance of NSCLC by activating endoplasmic reticulum stress. XAF1 promotes colorectal cancer metastasis via VCP-RNF114-JUP axis. IRF9 and XAF1 as Diagnostic Markers of Primary Sjogren Syndrome.

Nov 17, 2022 · The XAF1‐XIAP‐KLHL22 axis functions as a major regulator that controls IRF7 protein abundance and helps to maintain a proper level of this protein. XAF1 has been shown to regulate apoptosis and promote antitumor activity.