X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. [5] [6] The XBP1 gene is located on chromosome 22 while a closely related pseudogene has been identified and localized to chromosome 5. [7]

2024年12月25日 · XBP1 (X-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with XBP1 include Major Affective Disorder 7 and Hematologic Cancer. Among its related pathways are Unfolded Protein Response (UPR) and …

As the most conserved signaling branch of UPR, the IRE1-XBP1 pathway plays an important role in both physiological and pathological states, and its activity has a profound impact on disease progression and prognosis.

2020年8月8日 · Xbp1s进入细胞核后会启动一系列基因转录 (如脂质合成、ERAD等)，从多个层次缓解内质网应激。 除此之外p-IRE1α可以通过RIDD过程促进mRNA的降解，减缓新生多肽链合成，降低内质网压力。 （这个过程是不是很像学校（内质网）丧心病狂的把幼儿园的小孩（mRNA）全灭了，来年肯定没有新生（多肽链）入学了，学校可以专心收拾现有的学生了） p-IRE1α还可以通过TRAF2催化JNK和Caspase-12介导的信号通路，促进细胞凋亡。 （这大概 …

2021年7月8日 · The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) stress, unspliced Xbp1 mRNA is cleaved by the activated stress sensor IRE1α and converted to the mature form encoding spliced XBP1 (XBP1s). Translated XBP1s ...

2022年11月11日 · 该研究发现，肿瘤细胞内IRE1α/XBP1信号通路的活化通过促进自身胆固醇的合成和分泌，抑制抗肿瘤免疫，促进了肿瘤生长。 研究人员首先通过比较TCGA和GTEx数据库中肿瘤组织和正常组织中XBP1 mRNA表达水平，发现肿瘤组织中XBP1高表达。 进而选取黑色素瘤和结肠癌细胞并接种到小鼠身上，观察到肿瘤组织IRE1α/XBP1通路的激活。 接下来，研究者构建了IRE1α或者XBP1缺失的肿瘤细胞，发现该UPR通路的缺失能有效抑制肿瘤在野生型小鼠上的 …

2016年10月18日 · The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes ...

由未剪接的 mRNA XBP1 (U) 编码的亚型组成型表达，并被认为作为 XBP1 (S) 的负反馈调节剂起作用，它在 ER 应激的恢复阶段关闭靶基因的转录。 XBP1 的假基因已被识别并定位于 5 号染色体。 [RefSeq 提供，2008 年 7 月] This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box.

小鼠研究发现，在肝细胞中条件性敲除XBP1可导致脂肪蓄积减少，然而在巨噬细胞中敲除XBP1基因可以减轻营养性脂肪性肝炎和纤维化。 抑制XBP1的药物可能减轻脂肪肝炎和肝纤维化，提示XBP1是NASH潜在治疗靶点。 正文解读. 研究背景. NASH的特征是肝内脂肪过度蓄积、脂质代谢紊乱。 脂毒性可通过炎症，启动和加速肝细胞损伤，从而引发NASH。 研究表明，脂质代谢紊乱、巨噬细胞相关炎症在调控NASH进展中发挥关键作用。 此外，糖脂代谢、胆酸毒性、肝星状细 …

In response to increased demand on the protein folding capacity of the ER, UPR-mediated splicing of XBP1 mRNA yields the XBP1(S) transcriptional activator. We propose that XBP1(S) induces expression of unknown gene products that lead to an increase in CCT activity and a large increase in CPT activity, thereby augmenting synthesis of PtdCho.