XBP1 - Wikipedia
X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. [5] [6] The XBP1 gene is located on chromosome 22 while a closely related …
XBP1 Gene - GeneCards | XBP1 Protein | XBP1 Antibody
Dec 25, 2024 · XBP1 (X-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with XBP1 include Major Affective Disorder 7 and Hematologic Cancer. Among its related …
X-box binding protein 1 (XBP1) function in diseases - PubMed
As the most conserved signaling branch of UPR, the IRE1-XBP1 pathway plays an important role in both physiological and pathological states, and its activity has a profound impact on disease …
详解内质网应激/未折叠蛋白反应三条信号通路 - 简书
Aug 8, 2020 · Xbp1s进入细胞核后会启动一系列基因转录 (如脂质合成、ERAD等)，从多个层次缓解内质网应激。 除此之外p-IRE1α可以通过RIDD过程促进mRNA的降解，减缓新生多肽链合 …
Roles of XBP1s in Transcriptional Regulation of Target Genes
Jul 8, 2021 · The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum …
Cell子刊：王立堃团队发现抑制XBP1/胆固醇信号，可提高癌症免 …
Nov 11, 2022 · 该研究发现，肿瘤细胞内IRE1α/XBP1信号通路的活化通过促进自身胆固醇的合成和分泌，抑制抗肿瘤免疫，促进了肿瘤生长。 研究人员首先通过比较TCGA和GTEx数据库中 …
XBP1 X-box binding protein 1 - NIH Genetic Testing Registry …
Oct 18, 2016 · The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by …
X-box 结合蛋白 1（XBP1）基因 | MCE - MCE-生物活性分子大师
由未剪接的 mRNA XBP1 (U) 编码的亚型组成型表达，并被认为作为 XBP1 (S) 的负反馈调节剂起作用，它在 ER 应激的恢复阶段关闭靶基因的转录。 XBP1 的假基因已被识别并定位于 5 号染 …
杨乃彬医生团队解读：XBP1在调控NASH进展中的作用|肝细胞|小 …
小鼠研究发现，在肝细胞中条件性敲除XBP1可导致脂肪蓄积减少，然而在巨噬细胞中敲除XBP1基因可以减轻营养性脂肪性肝炎和纤维化。 抑制XBP1的药物可能减轻脂肪肝炎和肝纤维化，提 …
XBP1: a link between the unfolded protein response, lipid …
In response to increased demand on the protein folding capacity of the ER, UPR-mediated splicing of XBP1 mRNA yields the XBP1(S) transcriptional activator. We propose that XBP1(S) …