X-box binding protein 1: A new metabolic mediator and drug
2022年11月11日 · Our preliminary results demonstrate that metformin activates AMPK to reduce TG synthesis by inhibiting the XBP1-mediated DGAT2 pathway, at least in part, suggesting …
Genetic and pharmacological inhibition of XBP1 protects against …
2022年2月10日 · Genetic and pharmacological inhibition of Xbp1 specifically in hepatocytes ameliorated APAP-induced liver injury by enhancing autophagy and decreasing CYP2E1 …
详解内质网应激/未折叠蛋白反应三条信号通路 - 简书
2020年8月8日 · pPerk磷酸化下游的elF2，p-elF2可以促进转录因子ATF4翻译，ATF4功能与Xbp1s相似，通过启动一系列基因转录从多个层次缓解内质网应激。 内质网应激过于严 …
The IL-15–AKT–XBP1s signaling pathway contributes to ... - Nature
2018年12月10日 · Here we identified a signaling pathway—involving the serine-threonine kinase AKT and the transcription factor XBP1s, which regulates unfolded protein response genes 2, 3 …
Science | 发现全新的决定内质网应激下细胞命运的调控因子 - 知乎
研究人员验证了Xbp1s和Hspa5在Tm处理开始后的12和15小时最大程度地诱导，并在24小时后显着降低。 因此，当Xbp1s和Hspa5均被高度诱导（13小时）和表达水平减弱时（25小时）收 …
IRE1-XBP1 Pathway of the Unfolded Protein Response Is Required …
XBP1 deficiency abruptly increases apoptosis and autophagy, suggesting that XBP1 functions in moderating these events. Of note, we found that AMPK activation is increased in XBP1 …
Blimp-1 controls plasma cell function through the regulation of ...
2016年1月18日 · Blimp-1 regulated many components of the unfolded protein response (UPR), including XBP-1 and ATF6. The overlap in the functions of Blimp-1 and XBP-1 was restricted …
C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in …
2011年1月1日 · To examine the down-stream effectors of ER stress, we used a specific ER stress-induced protein X-box-binding protein 1 (XBP1) on AMPK activation. XBP1 is a key …
Cell子刊：王立堃团队发现抑制XBP1/胆固醇信号，可提高癌症免 …
2022年11月11日 · 研究者进一步利用质谱流式技术分析发现，肿瘤细胞内XBP1的缺失减少了肿瘤微环境中髓系来源的免疫抑制性细胞（myeloid-derived suppressor cell，MDSC），增加了活 …
AMPK-PERK axis represses oxidative metabolism and enhances …
AMP-activated protein kinase (AMPK) regulates the balance between cellular anabolism and catabolism dependent on energy resources to maintain proliferation and survival. Small …