详解内质网应激/未折叠蛋白反应三条信号通路 - 简书
2020年8月8日 · p-IRE1α接下来会催化一个重要的过程：使Xbp1 mRNA发生剪切，形成一个功能活跃的转录因子Xbp1s。 Xbp1s进入细胞核后会启动一系列基因转录(如脂质合成、ERAD等)， …
The emerging role of XBP1 in cancer - ScienceDirect
2020年7月1日 · XBP1 was first distinguished as a key regulator of major histocompatibility complex (MHC) class II gene expression in B cells. XBP1 communicates with the foremost …
科学网—非折叠蛋白反应和内质网应激 - 孙学军的博文
2014年9月9日 · 可见 BiP 是内质网应激的关键性调控分子，其中 BiP 和 XBP-1 表达上调常被用作内质网应激的标志。 大量研究表明，发生内质网应激的细胞能调节内质网应激相关性促凋亡 …
Pharmacologic IRE1/XBP1s activation confers targeted ER ... - Nature
2020年7月20日 · Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis …
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by …
2015年6月18日 · Accordingly, DC-specific XBP1 deletion or selective nanoparticle-mediated XBP1 silencing in tDCs restored their immunostimulatory activity in situ and extended survival …
The Role of BiP and the IRE1α–XBP1 Axis in Rhabdomyosarcoma …
2021年9月30日 · The expression of BiP (GRP78), spliced XBP1 (sXBP1, nuclear XBP1), and IRE1α, were significantly associated with Rhabdomyosarcoma (RMS) in the four main RMS …
The Role of BiP and the IRE1α-XBP1 Axis in Rhabdomyosarcoma ... - PubMed
2021年9月30日 · At the subtype level, BiP and sXBP1 expression were significantly associated with all subtypes of RMS, whereas IRE1α was associated with ARMS, PRMS and ERMS, and …
Bip-Yorkie interaction determines oncogenic and tumor ... - PubMed
2022年10月10日 · Activation of Ire1/Xbp1s up-regulates their downstream target Bip, which sequesters Yorkie (Yki), a Hippo pathway transducer, in the cytoplasm to restrict Yki …
Bip-Yorkie 相互作用决定了 Ire1/Xbp1s 激活的致癌和肿瘤抑制作用 …
Activation of Ire1/Xbp1s up-regulates their downstream target Bip, which sequesters Yorkie (Yki), a Hippo pathway transducer, in the cytoplasm to restrict Yki transcriptional output. This …
Dryad | Data -- The role of BiP and the IRE1α-XBP1 axis in ...
2025年3月5日 · Comparison with IRE1 and BIP: IRE1: Acts upstream by splicing XBP1 mRNA, so high IRE1 expression correlates with high nuclear XBP1 levels. BIP: Works as a molecular …
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