2020年8月8日 · p-IRE1α接下来会催化一个重要的过程：使Xbp1 mRNA发生剪切，形成一个功能活跃的转录因子Xbp1s。 Xbp1s进入细胞核后会启动一系列基因转录(如脂质合成、ERAD等)，从多个层次缓解内质网应激。

Activation of IRE1α processes unspliced XBP-1 mRNA into activated XBP1(s), which enters the nucleus and controls the expression of CHOP. IRE1α activates the apoptotic signaling kinase 1 (ASK1), which in turn phosphorylates p38 MAPK/JNK, and activates CHOP.

The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) stress, unspliced Xbp1 mRNA is cleaved by the activated stress ...

2019年11月26日 · Knock down and overexpression studies showed that CHOP, IRE1α, XBP1, and JNK supported efficient virus proliferation. Our study demonstrates that the induction of eIF2α-CHOP-BCL-2/JNK and...

2014年8月1日 · Mechanism of transcriptional induction of CHOP by IRE1 in ER stress Activated IRE1 cleaves XBP-1 mRNA precursor to mature XBP-1 mRNA by unique splicing and produces an active transcription factor named spliced XBP1 (XBP1-S), which up-regulates ER chaperones and proteins implicated in the ERAD.

CHOP is one of the key downstream molecules known to be involved in ERS-mediated apoptosis. Collectively, these findings reveal a novel critical role of XBP1S in ERS-mediated apoptosis and the molecular mechanisms involved.

2015年7月5日 · CHOP, an endoplasmic reticulum stress-associated proapoptotic signal, is involved in downstream of XBP1S. In the present study, we explored the effect of XBP1S in modulating HG-induced apoptosis in renal MCs and then identified the role of …

2015年9月15日 · Here, we investigated the relationships between XBP1, CHOP and JNK in the transition from adaptive to apoptotic UPR and β-cell death in models of type 1 and type 2 diabetes. XBP1 inhibition potentiated cell death induced by pro-inflammatory cytokines or the saturated fatty acid palmitate in MIN6 β-cells.

2015年7月5日 · CHOP, an endoplasmic reticulum stress-associated proapoptotic signal, is involved in downstream of XBP1S. In the present study, we explored the effect of XBP1S in modulating HG-induced apoptosis in renal MCs and then identified the role of …

2020年11月20日 · Genetic deletion of XBP1 has multiple consequences: some resulting from the loss of the transcription factor per se, and others related to compensatory activation of IRE1α. The objective of the...