详解内质网应激/未折叠蛋白反应三条信号通路 - 简书
2020年8月8日 · p-IRE1α接下来会催化一个重要的过程：使Xbp1 mRNA发生剪切，形成一个功能活跃的转录因子Xbp1s。 Xbp1s进入细胞核后会启动一系列基因转录(如脂质合成、ERAD等)， …
The C/EBP Homologous Protein (CHOP) Transcription Factor …
Activation of IRE1α processes unspliced XBP-1 mRNA into activated XBP1(s), which enters the nucleus and controls the expression of CHOP. IRE1α activates the apoptotic signaling kinase …
Roles of XBP1s in Transcriptional Regulation of Target Genes
The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) stress, …
eIF2α-CHOP-BCl-2/JNK and IRE1α-XBP1/JNK signaling promote …
2019年11月26日 · Knock down and overexpression studies showed that CHOP, IRE1α, XBP1, and JNK supported efficient virus proliferation. Our study demonstrates that the induction of …
New insights into the roles of CHOP-induced apoptosis in ER stress
2014年8月1日 · Mechanism of transcriptional induction of CHOP by IRE1 in ER stress Activated IRE1 cleaves XBP-1 mRNA precursor to mature XBP-1 mRNA by unique splicing and …
XBP1S protects cells from ER stress-induced apoptosis through …
CHOP is one of the key downstream molecules known to be involved in ERS-mediated apoptosis. Collectively, these findings reveal a novel critical role of XBP1S in ERS-mediated apoptosis …
CHOP mediates XBP1S-induced renal mesangial cell necrosis ... - PubMed
2015年7月5日 · CHOP, an endoplasmic reticulum stress-associated proapoptotic signal, is involved in downstream of XBP1S. In the present study, we explored the effect of XBP1S in …
The balance between adaptive and apoptotic unfolded protein …
2015年9月15日 · Here, we investigated the relationships between XBP1, CHOP and JNK in the transition from adaptive to apoptotic UPR and β-cell death in models of type 1 and type 2 …
CHOP mediates XBP1S-induced renal mesangial cell
2015年7月5日 · CHOP, an endoplasmic reticulum stress-associated proapoptotic signal, is involved in downstream of XBP1S. In the present study, we explored the effect of XBP1S in …
Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury ...
2020年11月20日 · Genetic deletion of XBP1 has multiple consequences: some resulting from the loss of the transcription factor per se, and others related to compensatory activation of IRE1α. …