Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 ... - Cell Press
2014年11月6日 · IRE1, an endoplasmic reticulum (ER) kinase/RNase, splices XBP1/HAC1 to produce an active transcription factor but also cleaves ER-associated mRNA through …
Crucial roles of Grr1 in splicing and translation of HAC1 mRNA …
2025年3月4日 · In the UPR signaling pathway, HAC1 mRNA in budding yeast 32,33,34 or XBP1 mRNA in metazoans 32,33,34 is targeted to the ER-resident protein kinase and endonuclease …
XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response …
2001年12月28日 · HAC1 mRNA encodes the basic leucine zipper (bZIP)-type transcription factor Hac1p, which directly activates transcription of UPR target genes. Hac1p is synthesized only …
ER stress signaling by regulated splicing: IRE1/HAC1/XBP1
Here, we summarize various approaches to study the IRE1-Hac1 pathway in yeast and the homologous IRE1-XBP1 pathway in mammalian cells. We present microbiological growth …
Ire1 has distinct catalytic mechanisms for XBP1/HAC1 splicing
2014年11月6日 · An evolutionarily conserved unfolded protein response (UPR) component, IRE1, cleaves XBP1/HAC1 introns in order to generate spliced mRNAs that are translated into potent …
Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay
2022年3月24日 · We show that Pumilio protects Drosophila Xbp1 against RIDD, without perturbing canonical Ire1-driven Xbp1 splicing. Furthermore, we provide evidence that Ire1 …
ER stress signaling by regulated splicing: IRE1/HAC1/XBP1
2005年4月1日 · In the following report, we describe a variety of methods used to arrive at our current understanding of yeast IRE1-dependent HAC1 splicing and mammalian IRE1α …
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response …
2001年12月28日 · In yeast, the transmembrane protein kinase/endoribonuclease Ire1p activated by endoplasmic reticulum stress cleaves HAC1 mRNA, leading to production of the …
Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing …
An evolutionarily conserved unfolded protein response (UPR) component, IRE1, cleaves XBP1/HAC1 introns in order to generate spliced mRNAs that are translated into potent …
2014年11月6日 · Using in vitro experiments, we found that IRE1 has two different modes of action: is cleaved XBP1/HAC1 by IRE1 subunits acting cooperatively within IRE1 oligomers, …