Intracellular XBP1-IL-24 axis dismantles cytotoxic unfolded protein ...
2020年1月6日 · Here we identified an antiapoptotic role of IL-24, which transiently accumulated within ER-stressed hepatocytes in a X-box binding protein 1 (XBP1)-dependent manner. …
IRE1α-XBP1 signaling pathway regulates IL-6 expression and
Ectopic expression of IRE1α or XBP1s increased IL-6 levels in LO2 and Hep3B cells. In addition, pharmacological inhibition of IRE1α reduced the levels of IL-6 expression and secretion …
The IL-15-AKT-XBP1s signaling pathway contributes to effector
Here we identified a signaling pathway-involving the serine-threonine kinase AKT and the transcription factor XBP1s, which regulates unfolded protein response genes 2,3-that was …
Roles of XBP1s in Transcriptional Regulation of Target Genes
An IRE1α RNase inhibitor, 4μ8C, blocks Xbp1 splicing and attenuates IL-6 expression in HCC. XBP1s regulates the transcription of nuclear receptor coactivator 3 (NCOA3) in luminal/ER …
Unravel the molecular mechanism of XBP1 in regulating the …
IL-4 has been reported to promote the early B cells activation by suppression of inhibitory factors on B cells and sustainment of XBP1 expression during early differentiation. In contrast, IL-6 …
JCI - The IRE1α/XBP1 pathway sustains cytokine responses of …
2024年5月9日 · We show that mouse intestinal ILC3s exhibited a 24-hour rhythmic expression pattern of the master ER stress response regulator inositol-requiring kinase 1α/X-box–binding …
IRE1α-XBP1信号通路调节IL-6表达并促进肝细胞癌的进展 …
2018年9月15日 · 利用chip和萤光素酶报告基因检测xbp1与il-6启动子dna之间的相互作用。 令人鼓舞的是，IRE1α-XBP1信号传导通过调节肝IL-6表达促进HCC细胞的增殖。 观察到在人HCC组 …
Plasma cell differentiation and the unfolded protein response
2003年3月3日 · The expression of mouse Xbp1 and other genes involved in the UPR is controlled by interleukin-4 (IL-4), a cytokine that is crucial for B cell survival, whereas production of the …
Anti-apoptotic function of Xbp1 as an IL-3 signaling molecule in ...
2011年2月10日 · Inhibition of both PI3K and STAT5 pathways suppressed Xbp1S expression and apoptosis induction, suggesting that Xbp1 has the important role of anti-apoptotic factor in the …
Intracellular XBP1-IL-24 axis dismantles cytotoxic unfolded …
2020年1月6日 · Here we identified an antiapoptotic role of IL-24, which transiently accumulated within ER-stressed hepatocytes in a X-box binding protein 1 (XBP1)-dependent manner. …
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