Roles of XBP1s in Transcriptional Regulation of Target Genes
Under endoplasmic reticulum (ER) stress, unspliced Xbp1 mRNA is cleaved by the activated stress sensor IRE1α and converted to the mature form encoding spliced XBP1 (XBP1s). …
IRE1α–XBP1 safeguards hematopoietic stem and progenitor
2025年1月9日 · Here, we uncover unfolded protein response stress sensor inositol-requiring enzyme-1α (IRE1α) signaling in hematopoietic stem and progenitor cells (HSPCs) as a …
The transcription factor XBP1 in dendritic cells promotes the T
2023年6月27日 · We verified this result with IP experiments, in which we detected a complex containing XBP1 and SOS1 in the protein extracts of IL-2–primed DCs (Fig. 4, E and F). To …
Farnesoid X receptor signaling activates the hepatic X-box …
The inositol-requiring enzyme 1α/X-box binding protein 1 (IRE1α/XBP1) pathway of the unfolded protein response (UPR) is a protective cellular signaling pathway activated in response to …
X-box binding protein 1 (XBP1) function in diseases - PubMed
As the most conserved signaling branch of UPR, the IRE1-XBP1 pathway plays an important role in both physiological and pathological states, and its activity has a profound impact on disease …
Unravel the molecular mechanism of XBP1 in regulating the …
Spliced XBP1 (XBP1s) is the direct downstream factor of IRE1α with activated RNase activity through splicing and removing 26 nucleotide intron from un-spliced XBP1 (XBP1u) (Figure 1), …
Targeting the IRE1α-XBP1s axis confers selective ... - Nature
2024年2月28日 · In this study, we show that XBP1s, the major downstream effector of IRE1α, is required for HCC cell survival both in vitro and in vivo. Mechanistically, XBP1s transactivates …
Hypoxia-activated XBP1s recruits HDAC2-EZH2 to engage ... - Nature
2024年2月27日 · In this study, we demonstrate that hypoxia promotes breast cancer metastasis through suppression of ΔNp63α in a HIF1α-independent manner. We show that hypoxia …
文献学习004——未剪切的XBP1 & β-Catenin互作抑制血管钙化
2023年7月14日 · XBP1u (unspliced X-box binding protein 1) inhibits vascular smooth muscle cell (VSMC) calcification in vitro. 体外实验证实（降低和过表达），XBP1u抑制血管平滑肌细胞钙 …
X-box 结合蛋白 1（XBP1）基因 | MCE - MCE-生物活性分子大师
由未剪接的 mRNA XBP1 (U) 编码的亚型组成型表达，并被认为作为 XBP1 (S) 的负反馈调节剂起作用，它在 ER 应激的恢复阶段关闭靶基因的转录。 XBP1 的假基因已被识别并定位于 5 号染 …