2021年3月16日 · FoxO1 governs lipid accumulation in cardiomyocytes, and overexpression of Xbp1s triggers FoxO1 ubiquitination and proteasomal degradation. Using gain- and loss-of …

Hyperactivated IRE1α in the XBP1-deficient liver degrades the lipid metabolism-associated mRNAs involved in lipogenesis (Dgat2, Acacb, and Scd1) and lipoprotein metabolism …

XBP1 decreased glucose dysfunction via funneling its effects on improving insulin sensitivity and stimulating insulin secretion. However, XBP1 also yields its double-edged effects, driving the …

2016年3月1日 · X-box binding protein 1 (XBP1) is a major, well-conserved component of the unfolded protein response (UPR) that is crucial for glucose homeostasis and lipid metabolism. …

Imanikia et al. find that expressing the transcription factor xbp-1s in C. elegans remodels lipid metabolism, decreasing triglyceride and increasing oleic acid (OA) levels. Increased OA levels …

2004年10月11日 · Cells overexpressing XBP1 (S) exhibit elevated levels of membrane phospholipids, increased surface area and volume of rough ER, and enhanced activity of the …

2022年8月6日 · Recent studies showed that unspliced XBP1 (XBP1-u) has unique biological functions independent from XBP1-s and could promote tumorigenesis; however, whether it is …

Genetic interaction and biochemical analyses revealed that Ire1 regulates lipid mobilization by promoting Xbp1s-associated FoxO degradation and suppressing FoxO-dependent lipolytic …

Cells overexpressing XBP1 (S) exhibit elevated levels of membrane phospholipids, increased surface area and volume of rough ER, and enhanced activity of the cytidine diphosphocholine …

XBP1-u promotes HCC cholesterol biosynthesis. To explore whether XBP1 was involved in lipid metabolism of tumor cells, we first silenced XBP1 in HCC-LM3, MHCC-97H, and HepG2 …