
Xbp1s-FoxO1 axis governs lipid accumulation and contractile ... - Nature
2021年3月16日 · FoxO1 governs lipid accumulation in cardiomyocytes, and overexpression of Xbp1s triggers FoxO1 ubiquitination and proteasomal degradation. Using gain- and loss-of …
Roles of XBP1s in Transcriptional Regulation of Target Genes
Hyperactivated IRE1α in the XBP1-deficient liver degrades the lipid metabolism-associated mRNAs involved in lipogenesis (Dgat2, Acacb, and Scd1) and lipoprotein metabolism …
The Multiple Roles of XBP1 in Regulation of Glucose and Lipid ...
XBP1 decreased glucose dysfunction via funneling its effects on improving insulin sensitivity and stimulating insulin secretion. However, XBP1 also yields its double-edged effects, driving the …
XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid ...
2016年3月1日 · X-box binding protein 1 (XBP1) is a major, well-conserved component of the unfolded protein response (UPR) that is crucial for glucose homeostasis and lipid metabolism. …
XBP-1 Remodels Lipid Metabolism to Extend Longevity - Cell Press
Imanikia et al. find that expressing the transcription factor xbp-1s in C. elegans remodels lipid metabolism, decreasing triglyceride and increasing oleic acid (OA) levels. Increased OA levels …
XBP1: a link between the unfolded protein response, lipid
2004年10月11日 · Cells overexpressing XBP1 (S) exhibit elevated levels of membrane phospholipids, increased surface area and volume of rough ER, and enhanced activity of the …
Unspliced XBP1 contributes to cholesterol biosynthesis and ...
2022年8月6日 · Recent studies showed that unspliced XBP1 (XBP1-u) has unique biological functions independent from XBP1-s and could promote tumorigenesis; however, whether it is …
Fat body Ire1 regulates lipid homeostasis through the Xbp1s …
Genetic interaction and biochemical analyses revealed that Ire1 regulates lipid mobilization by promoting Xbp1s-associated FoxO degradation and suppressing FoxO-dependent lipolytic …
XBP1: a link between the unfolded protein response, lipid …
Cells overexpressing XBP1 (S) exhibit elevated levels of membrane phospholipids, increased surface area and volume of rough ER, and enhanced activity of the cytidine diphosphocholine …
Unspliced XBP1 contributes to cholesterol biosynthesis and ...
XBP1-u promotes HCC cholesterol biosynthesis. To explore whether XBP1 was involved in lipid metabolism of tumor cells, we first silenced XBP1 in HCC-LM3, MHCC-97H, and HepG2 …