Hepatocyte-specific deletion of XBP1 sensitizes mice to liver …
2020年11月20日 · Fructose-mediated liver injury in Xbp1 Δhep mice coincided with heightened IRE1α activity, as demonstrated by Xbp1 mRNA splicing, JNK activation, and regulated IRE1α …
Role of XBP1 in regulating the progression of non-alcoholic ...
XBP1 is a transcription factor that is upregulated in liver tissues of patients with non-alcoholic steatohepatitis (NASH). Conditional knockout of Xbp1 in hepatocytes resulted in decreased …
Hepatic IRE1α regulates fasting-induced metabolic adaptive ... - Nature
2014年3月27日 · Hepatocyte-specific abrogation of Ire1 α results in impairment of fatty acid β-oxidation and ketogenesis in the liver under chronic fasting or ketogenic conditions, leading to …
Targeting the IRE1α-XBP1s axis confers selective ... - Nature
2024年2月28日 · In this study, we show that XBP1s, the major downstream effector of IRE1α, is required for HCC cell survival both in vitro and in vivo. Mechanistically, XBP1s transactivates …
XBP1 deficiency promotes hepatocyte pyroptosis by impairing
Hepatocellular cell death and macrophage proinflammatory activation contribute to the pathology of various liver diseases, during which XBP1 plays an important role. However, the function …
Roles of X-box binding protein 1 in liver pathogenesis - PubMed
2024年10月2日 · XBP1 interacts with a key signaling component of the highly conserved UPR and is critical in determining cell fate when responding to ER stress in liver diseases. This …
X-box Binding Protein 1 Regulates Unfolded Protein, Acute-Phase…
2017年4月1日 · We investigated the role of the core unfolded protein response transcription factor X-box binding protein 1 (XBP1) in liver regeneration using genome-wide chromatin …
An essential role in liver development for transcription factor XBP-1
XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed …
XBP1 deficiency promotes hepatocyte pyroptosis by impairing …
2022年6月1日 · Hepatocellular cell death and macrophage innate immune activation contribute to the pathology of various liver diseases, during which XBP1 plays an important role. However, …
Role of XBP1 in regulating the progression of non-alcoholic ...
2022年8月1日 · XBP1 is a transcription factor that is upregulated in liver tissues of patients with non-alcoholic steatohepatitis (NASH). Conditional knockout of Xbp1 in hepatocytes resulted in …