Roles of XBP1s in Transcriptional Regulation of Target Genes
Enriched DNA motifs of those regions revealed the XBP1s-binding motif contained the consensus sequence CACGT and NF-Y-binding motif. XBP1s target genes and their transcriptional …
Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1…
2021年10月12日 · Using next‐generation sequencing (NGS) followed by bioinformatic analysis of XBP1-binding motifs, and validation using XBP1-specific silencing and quantitative real‐time …
XBP1 Gene - GeneCards | XBP1 Protein | XBP1 Antibody
2024年12月25日 · XBP1 (X-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with XBP1 include Major Affective Disorder 7 and Hematologic Cancer. Among its …
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes …
2018年10月24日 · To further characterize the XBP1 regulome, we performed de novo motif discovery using HOMER to identify enriched DNA motifs within XBP1 binding regions. The top …
Systematic identification of cell-fate regulatory programs using a ...
2022年7月11日 · In particular, we identified Xbp1 as an evolutionarily conserved regulator of cell-fate determinations across different species. We demonstrated that Xbp1 transcriptional …
Roles of XBP1s in Transcriptional Regulation of Target Genes
2021年7月8日 · The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic …
Emerging Roles for XBP1, a sUPeR Transcription Factor - PMC
X-box binding protein 1 (XBP1) is a unique basic region leucine zipper (bZIP) transcription factor whose active form is generated by a nonconventional splicing reaction upon disruption of …
A negative feedback loop between XBP1 and Fbw7 regulates
2019年2月19日 · Here we show that Fbw7, a substrate recognition component of the SKP1-Cullin-F-box-type E3 ligase, interacts with XBP1 in a phosphorylation-dependent manner, and …
Xbp1 targets canonical UPRER and non-canonical pathways in …
The non-canonical role of Xbp1 s in the fat body and its ability to promote longevity prompted us to further explore its function in this organ. Firstly, we performed motif enrichment analysis on …
X-box binding protein 1 (XBP1) function in diseases - PubMed
As the most conserved signaling branch of UPR, the IRE1-XBP1 pathway plays an important role in both physiological and pathological states, and its activity has a profound impact on disease …