2021年1月20日 · In insulin-producing β-cells, PAIRs permit adaptive splicing of Xbp1 mRNA while quelling destructive ER mRNA endonucleolytic decay and apoptosis. By preserving Xbp1 mRNA splicing, PAIRs allow B cells to differentiate into immunoglobulin-producing plasma cells.

2024年12月25日 · XBP1 (X-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with XBP1 include Major Affective Disorder 7 and Hematologic Cancer. Among its related pathways are Unfolded Protein Response (UPR) and …

2021年7月1日 · See Model Confidence metrics below for all regions of the polypeptide chain. Computed Structure Models provide per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation. Assembly. Explore in 3D: Structure | Sequence Annotations.

2025年2月8日 · Title: X-Box binding protein 1 downregulates SIRT6 to promote injury in pancreatic ductal epithelial cells. The IRE1alpha-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection.

2010年10月1日 · We show that the Xbp1-specific ribonuclease activity depends on autophosphorylation, and that ATP-competitive inhibitors staurosporin and sunitinib, which inhibit autophosphorylation in vitro, also inhibit Xbp1 splicing in vivo.

Isoform 2 interacts with PIK3R1; the interaction is direct and induces translocation of XBP1 isoform 2 into the nucleus and the unfolded protein response (UPR) XBP1-dependent target genes activation in a ER stress- and/or insulin-dependent but …

2016年10月18日 · The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]

2015年7月6日 · Here we discovered an unexpectedly selective and absolute requirement for XBP1 in eosinophil differentiation without an effect on the survival of basophils or neutrophils.

由未剪接的 mRNA XBP1 (U) 编码的亚型组成型表达，并被认为作为 XBP1 (S) 的负反馈调节剂起作用，它在 ER 应激的恢复阶段关闭靶基因的转录。 XBP1 的假基因已被识别并定位于 5 号染色体。 [RefSeq 提供，2008 年 7 月] This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box.

2003年3月3日 · Here we show that UPR-induced splicing of XBP-1 by the transmembrane endonuclease IRE1 is required to restore production of immunoglobulin in XBP-1 −/− mouse B cells, providing an integral link...