
Molecular Mechanism Underlying Role of the XBP1s in …
In this research, we provide a summary of the functions that XBP1s performs in the onset and advancement of CVDs such as atherosclerosis, hypertension, cardiac hypertrophy, and heart …
Roles of XBP1s in Transcriptional Regulation of Target Genes
Translated XBP1s migrates to the nucleus and regulates the transcriptional programs of UPR target genes encoding ER molecular chaperones, folding enzymes, and ER-associated protein …
The IRE1α/XBP1s Pathway Is Essential for the Glucose Response …
Here, we demonstrate that glucose activates the unfolded protein response transducer inositol-requiring enzyme 1 alpha (IRE1α) to initiate X-box-binding protein 1 (Xbp1) mRNA splicing in …
Roles of XBP1s in Transcriptional Regulation of Target Genes
2021年7月8日 · The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic …
Endoplasmic reticulum unfolded protein response transcriptional …
2024年7月25日 · Mammalian inositol-requiring enzyme 1 α (IRE1α) is a type I ER-membrane bound endoribonuclease that initiates spliceosome-independent mRNA splicing of X-box …
XBP1s 在靶基因转录调控中的作用,Biomedicines - X-MOL
X-box 结合蛋白 1 (XBP1s) 的剪接形式是一种活性转录因子,在未折叠蛋白反应 (UPR) 中起着至关重要的作用。在内质网 (ER) 胁迫下,未剪接的 Xbp1 mRNA 被激活的压力传感器 IRE1α 切割 …
Xbp1s-FoxO1 axis governs lipid accumulation and contractile ... - Nature
2021年3月16日 · Our findings uncover the Xbp1s-FoxO1 axis as a pivotal mechanism in the pathogenesis of cardiometabolic HFpEF and unveil previously unrecognized mechanisms …
XBP1s activates METTL3/METTL14 for ER-phagy and paclitaxel
2024年8月1日 · In this study, we first found that ER stress could dramatically elevate m6A methylation levels through XBP1s-dependent transcriptional upregulation of …
Targeting the IRE1α-XBP1s axis confers selective ... - Nature
2024年2月28日 · In this study, we show that XBP1s, the major downstream effector of IRE1α, is required for HCC cell survival both in vitro and in vivo. Mechanistically, XBP1s transactivates …
Unravel the molecular mechanism of XBP1 in regulating the …
Spliced XBP1 (XBP1s) is the direct downstream factor of IRE1α with activated RNase activity through splicing and removing 26 nucleotide intron from un-spliced XBP1 (XBP1u) (Figure 1), …