In this research, we provide a summary of the functions that XBP1s performs in the onset and advancement of CVDs such as atherosclerosis, hypertension, cardiac hypertrophy, and heart …

Translated XBP1s migrates to the nucleus and regulates the transcriptional programs of UPR target genes encoding ER molecular chaperones, folding enzymes, and ER-associated protein …

Here, we demonstrate that glucose activates the unfolded protein response transducer inositol-requiring enzyme 1 alpha (IRE1α) to initiate X-box-binding protein 1 (Xbp1) mRNA splicing in …

2021年7月8日 · The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic …

2024年7月25日 · Mammalian inositol-requiring enzyme 1 α (IRE1α) is a type I ER-membrane bound endoribonuclease that initiates spliceosome-independent mRNA splicing of X-box …

X-box 结合蛋白 1 (XBP1s) 的剪接形式是一种活性转录因子，在未折叠蛋白反应 (UPR) 中起着至关重要的作用。在内质网 (ER) 胁迫下，未剪接的 Xbp1 mRNA 被激活的压力传感器 IRE1α 切割 …

2021年3月16日 · Our findings uncover the Xbp1s-FoxO1 axis as a pivotal mechanism in the pathogenesis of cardiometabolic HFpEF and unveil previously unrecognized mechanisms …

2024年8月1日 · In this study, we first found that ER stress could dramatically elevate m6A methylation levels through XBP1s-dependent transcriptional upregulation of …

2024年2月28日 · In this study, we show that XBP1s, the major downstream effector of IRE1α, is required for HCC cell survival both in vitro and in vivo. Mechanistically, XBP1s transactivates …

Spliced XBP1 (XBP1s) is the direct downstream factor of IRE1α with activated RNase activity through splicing and removing 26 nucleotide intron from un-spliced XBP1 (XBP1u) (Figure 1), …