2023年5月9日 · Here, we found that Th17 cell-inducing gut bacteria generated an unfolded protein response (UPR) in IECs. Furthermore, subtilase cytotoxin expression or genetic …

XBP1 also coordinates changes in cellular structure and function, as demonstrated by improvement of cell size, lysosome content, mitochondrial mass and function, ribosome …

ER stress inducers, tunicamycin, thapsigargin, and CPA, also enhance Th17 cell polarization; however, the treatment of stress inhibitor or XBP1 deficiency in naive T cells reduces Th17 cell …

Here, we found that Th17 cell-inducing gut bacteria generated an unfolded protein response (UPR) in IECs. Furthermore, subtilase cytotoxin expression or genetic removal of X-box …

Xbp1ΔIEC 或Duox2ΔIECXbp1ΔIEC 肠道内Th17细胞比Xbp1ΔIEC小鼠减少了。从而证明肠上皮细胞内质网应激通过上调 Duoxa2和Duox2基因表达促进Th17细胞的分化（Figure 4G-H）。 …

2023年6月30日 · In this study, we investigated the role of the UPR sensor IRE1 in TH17 cell function and neutrophilic airway inflammation. We found that IRE1 is induced in fungal asthma …

2025年2月10日 · Assays for dual luciferase reporter and molecular docking indicated that XBP1s protein regulated the transcription of MAP3K2 by modulating promoter activity. The …

2023年4月5日 · Analyses in Xbp1ΔIEC mice revealed that increased concentrations of purine metabolites (such as xanthine) contributed to IEC-ER stress T H 17 cell induction. In addition, …

Splicing of XBP1 mRNA was recognized in both intestinal compartments of IBD patients when compared to controls. Conclusions: In IBD patients, both intestinal compartments are involved …

2021年7月8日 · ER stress inducers, tunicamycin, thapsigargin, and CPA, also enhance Th17 cell polarization; however, the treatment of stress inhibitor or XBP1 deficiency in naive T cells …