Roles of XBP1s in Transcriptional Regulation of Target Genes
2021年7月8日 · The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic …
Roles of XBP1s in Transcriptional Regulation of Target Genes
The spliced Xbp1 mRNA is translated by frameshift into an active transcription factor, XBP1s. Then, XBP1s upregulates the expression of UPR target genes, including ER chaperones, …
The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA …
2014年12月17日 · Active UPR signaling leads to unconventional, enzymatic splicing of XBP1 mRNA enabling expression of the transcription factor XBP1s to control ER homeostasis. While …
Real-time PCR quantification of spliced X-box binding protein 1 (XBP1 …
2019年7月22日 · X-box binding protein 1 (XBP1) mRNA processing plays a crucial role in the unfolded protein response (UPR), which is activated in response to endoplasmic reticulum …
XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response …
2001年12月28日 · Here, we identified the transcription factor XBP1, a target of ATF6, as a mammalian substrate of such an unconventional mRNA splicing system and showed that only …
Novel mechanism of enhancing IRE1α-XBP1 signalling via the …
2016年4月7日 · IRE1α has been known to splice X-box binding protein 1 (XBP1) mRNA, which is induced by ATF6 under ER stress. This spliced XBP1 mRNA is translated into the active …
Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1…
2021年10月12日 · IRE1 activates a transcription factor, X-box-binding protein 1 (XBP1), by removing a 26-base intron from XBP1 mRNA that generates spliced XBP1 mRNA (XBP1s). To …
Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay
2022年3月24日 · We show that Pumilio protects Drosophila Xbp1 against RIDD, without perturbing canonical Ire1-driven Xbp1 splicing. Furthermore, we provide evidence that Ire1 …
XBP1 - Wikipedia
Activated IRE1 catalyses the excision of a 26 nucleotide unconventional intron from ubiquitously expressed XBP1u mRNA, in a manner mechanistically similar to pre-tRNA splicing. Removal …
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response …
2001年12月28日 · Here, we identified the transcription factor XBP1, a target of ATF6, as a mammalian substrate of such an unconventional mRNA splicing system and showed that only …