2016年3月23日 · Activated intestinal T cells produce XCL1, which attracts nearby XCR1 + DC; the ensuing DC-T cell crosstalk supports T cell survival, promotes upregulation of CD103 expression with...

在驻留性dc中，作者观察到xcr1表达cd103–和cd103+的两个cdc1亚群，而cdc2则分为cd172a-xcr1-dn dc，以及表达cd11b–和cd11b+的两个cdc2亚群（图3.f）。 接下来，我们将探讨如何对DC细胞进行分选。

Cross-presenting dendritic cells (DCs) in the spleen develop into XCR1+ DCs in the small intestine, T cell zones of Peyer's patches, and T cell zones and sinuses of mesenteric lymph nodes. XCR1+ DCs specialize in cross-presentations of orally applied antigens.

2012年2月10日 · Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of dendritic cell (DC) known to be involved in antigen cross-presentation. This review aims to summarize the known biology of the XCR1 receptor and its chemokine ligand XCL1, both in the mouse and the human.

Using the mouse model of chronic LCMV infection, we found that XCR1+ DCs are more resistant to infection and highly activated compared with SIRPα+ DCs. Exploiting XCR1+ DCs via Flt3L-mediated expansion or XCR1-targeted vaccination notably reinvigorates CD8+ T cells and improves virus control.

在本报告中，我们证明了XCR1仅在鼠CD8 + 树突状细胞（DC）上表达，并表明XCL1是该DC子集的有效且高度特异性的化学引诱剂。 在体内CD8 + DC上抗原识别后的8–36小时内，CD8 + T细胞会大量分泌XCL1 ，在此期间，会发生稳定的T细胞-DC相互作用。 在功能上，XCL1增加了抗原特异性CD8 + T细胞的库及其分泌IFN-γ的能力。 XCL1的缺乏削弱了对CD8 + 交叉呈递的抗原的细胞毒性的发展 DC。 因此，XCL1-XCR1轴成为体内有效细胞毒性免疫发展过程中不可或缺的组 …

2021年8月13日 · Our findings identify PD-L1 + and XCR1 + DC as region-specific physiologic regulators of intestinal homeostasis. A beneficial multi-ecosystem involving commensal microorganisms, dietary antigens,...

2020年2月28日 · In this review, we define the universal classification system for cross-presenting DCs, and the vital role of this subset in mediating anti-tumor immunity. Furthermore, we will detail methods of targeting these DCs both ex vivo and in vivo to boost their function and drive effective anti-tumor responses.

2009年11月20日 · In the present report we demonstrated that XCR1 is exclusively expressed on murine CD8 + dendritic cells (DCs) and showed that XCL1 is a potent and highly specific chemoattractant for this DC subset. CD8 + T cells abundantly secreted XCL1 8–36 hr after antigen recognition on CD8 + DCs in vivo, in a period in which stable T cell-DC ...

2011年11月1日 · In this article, we showed that LT-resident CD8α + DCs and NLT-derived CD103 + DCs specifically express XCR1 and are characterized by a unique transcriptional fingerprint, irrespective of their tissue of origin.