2003年7月21日 · The binding affinity of XNA can be tuned by combining different types of nucleotide monomers and conformational restriction of XNA monomers clearly leads to improved binding. We are currently exploring the binding mode of homo-pyrimidine XNA and optimizing the hybridization properties of XNA.

2015年12月15日 · We perform a comparative conformational analysis of XNA self-pairing and cross-pairing with natural nucleic acids and discuss their potential as genetic information carriers. Not surprisingly, the geometries of XNA duplexes cover a wide conformational range relative to standard DNA and RNA.

2012年7月10日 · Now in a paper in Science, Philipp Holliger and his colleagues 1 describe elegant experiments demonstrating that oligonucleotides with six different sugar backbones (xeno-nucleic acids, or XNAs)...

2022年4月22日 · 他们的LNA Oligo Optimizer 工具允许您将带有 LNA 的 DNA 序列输入网络界面并确定熔解温度；您还可以查看是否会有任何二级结构或自我互补。 XNA，例如 iG 和 iC，可以通过 IDT（集成 DNA 技术）整合到 PCR 引物和探针中。

2014年6月1日 · Recent advances in nucleic acid chemistry and polymerase engineering enable the synthesis, replication, and evolution of a range of synthetic genetic polymers (XNAs) with improved chemical and biological stability. We discuss the impact of this technology on the generation of XNA ligands, enzymes, and nanostructures with tailor-made chemistry.

2020年1月1日 · The evolution of xenonucleic acid (XNA) research has taken a few different paths. There has been a significant recent trend towards the employment of high-efficiency ‘click’ reactions (e.g., copper-catalyzed azide alkyne cycloaddition and radical thiol-ene addition) for the development of oligo xenonucleobases with alternative backbone ...

2019年7月7日 · To construct an XNA episome, XNA oligonucleotides are needed beyond what is currently possible with conventional solid-phase synthesis (∼30-mers). An efficient enzyme to join chemically synthesized XNA fragments would bring synthetic genetics to a next level.

Our oligos are made to your specifications with rigorous quality control and quick turnaround for use in a variety of applications, including PCR, cloning, sequencing, and gene detection. Explore the easy-to use ordering portals for your tube and plate oligos, our complex and large-scale oligo services, and additional resources below.

2024年8月16日 · One way to enzymatically produce XNA oligonucleotides is using a template-dependent polymerase to synthesize the XNA oligonucleotides from a DNA template.

2021年8月3日 · Xeno nucleic acids (XNAs) are analogues of DNA and RNA that have a non-ribose artificial scaffold. XNAs are possible prebiotic genetic carriers as well as alternative genetic systems in artificial life. In addition, XNA oligomers can be used as biological tools.