XPB - Wikipedia
XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.
XPB Images
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XPB, a subunit of TFIIH, is a target of the natural product triptolide
Jan 30, 2011 · We report that triptolide covalently binds to human XPB (also known as ERCC3), a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase activity, …
Nature：揭示蛋白XPC、TFIIH和XPA在DNA切除修复中识别DNA损 …
核苷酸切除修复 （nucleotide excision repair, NER）是一种修复由紫外线和 化学致癌物 引起的各种DNA损伤的重要机制。 许多被 诊断 为着色性干皮病（xeroderma pigmentosum, XP）的患 …
TFIIH: when transcription met DNA repair - Nature
May 10, 2012 · Mutations in three subunits of TFIIH (XPB, XPD and p8) give rise to the autosomal recessive disorders xeroderma pigmentosum (which is sometimes associated with Cockayne …
徐彦辉等团队连发4篇Nature/Science，系统解析预启动复合物的结 …
XPB是TFIIH核心的ATP依赖的DNA转移酶亚基，在启动子melting，启动子逃逸及转录启动中起作用。 CAK由CDK7，细胞周期蛋白H（CycH）和MAT1形成。 CDK7激酶使Pol II C末端结构 …
XPB: An unconventional SF2 DNA helicase - ScienceDirect
Mar 1, 2015 · XPB is an essential core subunit of the eukaryotic basal transcription factor complex TFIIH which plays a dual role in transcription and DNA repair: 1) to facilitate the melting of the …
XPB: An Essential Helicase Involved in Both Transcription
Apr 21, 2006 · Helicases are molecular motors known to unwind double-stranded DNA. In a recent issue of Molecular Cell, Fan et al. (2006) revealed the core structure of XPB helicase, a …
Conserved XPB Core Structure and Motifs for DNA Unwinding: …
Here, we determined crystal structures of an Archaeoglobus fulgidus XPB homolog (AfXPB) that characterize two RecA-like XPB helicase domains and discover a DNA damage recognition …
XPB: An unconventional SF2 DNA helicase - PubMed
XPB is an essential core subunit of the eukaryotic basal transcription factor complex TFIIH which plays a dual role in transcription and DNA repair: 1) to facilitate the melting of the promoter …