Xist (X-inactive specific transcript) is a non-coding RNA transcribed from the X chromosome of the placental mammals that acts as a major effector of the X-inactivation process. [5] It is a component of the Xic – X-chromosome inactivation centre [6] – along with two other RNA genes (Jpx and Ftx) and two protein genes (Tsx and Cnbp2). [7]

2024年12月25日 · XIST (X Inactive Specific Transcript) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with XIST include X Inactivation, Familial Skewed, 1 and Collecting Duct Carcinoma.

2021年3月18日 · 通过分析女性自身免疫病患者和covid-19感染者的单细胞转录组，作者发现在cd11c +非典型b细胞（abcs）中xist依赖性基因表达过度, 从而推断xist在这些细胞中失调无法确保x染色体失活。

2025年1月21日 · X染色体失活（XCI）领域的一个重要未解之谜是，Xist RNA如何特异性地浓缩在失活的X染色体（Xi）上。进一步研究发现，Xist的第一个外显子中存在一个核心位点（nucleation site），其作用是将新生的Xist转录本锚定在X失活中心（Xic），并促进其在Xi上的顺式扩散。

2025年2月20日 · Xist RNA initiates X inactivation as it spreads in cis across the chromosome. Here, we reveal a biophysical basis for its cis-limited diffusion. Xist RNA and HNRNPK together drive a liquid-liquid phase separation (LLPS) that encapsulates the chromosome. HNRNPK droplets pull on Xist and internalize the RNA.

Xist RNA is the master regulator of X-chromosome inactivation (XCI), the epigenetic process that equalizes the dosage of X-linked genes between female (XX) and male (XY) mammals

In this manuscript, we summarize the current knowledge about the mechanisms for XIST -mediated XCI and the roles of XIST in sex-biased diseases, and discuss potential therapeutic strategies targeting XIST. Keywords: Epigenetic regulation, Long noncoding RNA, Sex-biased diseases, X chromosome inactivation, XIST.

2015年8月15日 · We discuss recent advances in our knowledge of Xist-mediated silencing, focusing on Xist spreading, the nuclear organization of the inactive X chromosome, recruitment of the polycomb complex and the role of the nuclear matrix in the process of …

2024年6月4日 · We show that XIST triggers the deposition of polycomb-mediated repressive histone modifications and dampens the transcription of most X-linked genes in a SPEN-dependent manner, while XACT...

2020年10月26日 · 长非编码RNA Xist通过高浓度定位在X染色体内转录位点以及结合多种蛋白促进X染色体失活（X-chromosome inactivation，XCI）。 因此，XCI过程也被认为是理解RNA介导的蛋白招募驱动功能性区室化的研究范式。 为了揭开XCI过程中RNA对于促进细胞核内区室化形成过程的具体分子机制，近日，美国加州大学洛杉矶分校 Kathrin Plath 研究组与 Douglas. L. Black 研究组合作发文题为 A protein assembly mediates Xist localization and gene silencing， 发现Xist …