2018年12月7日 · Xrp1 is upregulated in RpL19 +/− loser cells as observed with a LacZ-reporter (A-A’). Overexpression of Xrp1 in the posterior compartment ( en-Gal4 ) induces apoptosis, as observed with an ...

2022年2月18日 · Accordingly, Xrp1 +/+ and Xrp1 +/-data were combined together to compare the effects of Rp mutations. We confirmed that LSU numbers were reduced in the RpL27A mutant, and extended this observation to mutation in a second RpL gene, RpL14 .

2021年10月4日 · Here, we report that the bZIP transcription factor Xrp1 is required for ATF4-independent PERK signaling. Cell-type-specific gene expression profiling in Drosophila indicated that delta-family glutathione-S-transferases (gstD) are prominently induced by the UPR-activating transgene Rh1G69D.

The Xrp1 mutation reduced Puc-LacZ expression in Rp +/− cells (Figures 1N and 1O). Because Xrp1 affected gene expression that occurred throughout Rp +/− tissues, not just in Rp +/− cells in close proximity to wild-type cells, we wondered whether Xrp1 might act directly in Rp +/− cells.

2021年12月16日 · Here we provide evidence that initial proteotoxic stress in RpS3/+ cells is Xrp1-independent. However, Xrp1 is sufficient to induce proteotoxic stress in otherwise wild-type cells and is necessary for the high levels of proteotoxic stress found in RpS3/+ cells.

Our findings show that cell competition is commonly driven by Xrp1-mediated phosphorylation of eIF2α and that ER stress or other environmental stresses activating integrated stress response signaling, which converge on the phosphorylation of eIF2α, could be a …

Here, we report that the bZIP transcription factor Xrp1 is required for ATF4-independent PERK signaling. Cell-type-specific gene expression profiling in Drosophila indicated that delta-family glutathione-S-transferases (gstD) are prominently induced …

2024年2月2日 · Our work provides novel insights into the crosstalk between splicing and the DNA damage response and defines the Xrp1-Irbp18 heterodimer as a critical sensor of spliceosome malfunction and mediator of the stress-induced cellular senescence program.

In loser cells, Xrp1 is transcriptionally upregulated by an autoregulatory loop and is able to trigger apoptosis - driving cell elimination. We further show that Xrp1 acts in the nucleus to...

2021年12月16日 · We find that Xrp1 and Irbp18 promote protein aggregate formation and that, vice versa, protein aggregates induce Xrp1 and Irbp18 activity. This amplifies stress signalling and reduces the fitness of Minute cells, leading to their removal from tissues through cell competition.