Xun Li - Google Scholar
Postdoctoral fellow, UCSF - Cited by 461 - Synthetic Biology - Genome Engineering - Immune cell engineering
Precise CRISPR-Cas9 gene repair in autologous memory T cells
2024年2月2日 · Familial hemophagocytic lymphohistiocytosis (FHL) is an inherited, often fatal immune deficiency characterized by severe systemic hyperinflammation. Although allogeneic bone marrow transplantation can be curative, more effective therapies are urgently needed. FHL is caused by inactivating mutations in proteins that regulate cellular immunity.
Precise CRISPR-Cas–mediated gene repair with minimal off ... - AAAS
2022年6月3日 · Using spacer-nick, we developed an approach to repair disease-causing mutations occurring in the HBB, ELANE, IL7R, and PRF1 genes. We achieved gene correction …
Precise CRISPR-Cas-mediated gene repair with minimal off
2022年6月3日 · Using spacer-nick, we developed an approach to repair disease-causing mutations occurring in the HBB, ELANE, IL7R, and PRF1 genes. We achieved gene correction efficiencies of 20 to 50% with minimal NHEJ-mediated on-target mutations.
Xun Li's research works | Max-Delbrück-Centrum für Molekulare …
Xun Li's 11 research works with 259 citations and 1,556 reads, including: Prox2 and Runx3 vagal sensory neurons regulate esophageal motility
Gene editing precisely repairs immune cells | Max Delbrück Center
Xun Li et al (2024): „Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis“. Science Immunology, DOI: 10.1126/sciimmunol.adi0042
Genschere repariert defekte Immunzellen präzise - Max Delbrück …
Xun Li et al (2024): „Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis“. Science Immunology, DOI: 10.1126/sciimmunol.adi0042
<br>自体记忆 T 细胞中的精确 CRISPR-Cas9 基因修复治疗家族性 …
家族性噬血细胞性淋巴组织细胞增多症 (FHL) 是一种遗传性的、通常致命的免疫缺陷，其特征是严重的全身过度炎症。 尽管同种异体骨髓移植可以治愈，但迫切需要更有效的治疗方法。 FHL 是由调节细胞免疫的蛋白质失活突变引起的。 在这里，我们使用基于腺相关病毒的 CRISPR-Cas9 系统和非同源末端连接抑制剂来离体修复潜在长寿 T 细胞中的此类突变。 修复的 CD8 记忆 T 细胞有效治愈了 Epstein-Barr 病毒触发的 FHL2（一种由穿孔素-1 引起的亚型）小鼠模型中的致命性过 …
LMP1 and EBNA2 constitute a minimal set of EBV genes for
2023年12月19日 · LMP1/EBNA2-immortalized cell lines shared surface markers with EBV-transformed lymphoblastoid cell lines (LCLs). They showed sustained growth for more than 60 days, albeit at a lower growth rate than EBV-transformed LCLs. LMP1/EBNA2-immortalized cell lines generated tumors when transplanted subcutaneously …
Xun Li (AG Rajewsky) CRISPR/Cas9 mediated gene repair in T cells for primary immunodeficiency in mice
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