YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes involved in cellular proliferation and suppressing apoptotic genes.

2024年12月25日 · YAP1 (Yes1 Associated Transcriptional Regulator) is a Protein Coding gene. Diseases associated with YAP1 include Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/Palate, And/Or Impaired Intellectual Development and Uveal Coloboma-Cleft Lip And Palate-Intellectual Disability.

2025年3月8日 · Yes-associated protein (YAP) modulates oncogenic features and radiation sensitivity in endometrial cancer. Tsujiura M, et al. PLoS One, 2014. PMID 24972085, Free PMC Article. Inhibition of yes-associated protein suppresses migration, invasion, and metastasis in non-small cell lung cancer in vitro and in vivo.

The YAP1-activated (YA) subgroup showed worse prognosis for HNSCC as tested and validated in five cohorts. In a multivariate risk analysis, the YAP1 signature was the most significant predictor of overall survival. The YAP1-inactivated (YI) …

YAP1 promotes TEAD4 binding to the enhancer region of TIAM1, thereby activating TIAM1 expression, increasing RAC1 activity, and subsequently inducing invadopodia formation and metastasis in breast cancer 12.

2025年1月10日 · YAP1 is a potential novel prognostic marker in ACC patients. Its deregulation contributes to adrenocortical tumorigenesis partially through crosstalk between Hippo/YAP1 and Wnt/beta-catenin pathways. YAP1 inhibition is a new antitumor target.

Yes-associated protein (YAP)-1 is highly upregulated in pancreatic cancer and associated with tumor progression. However, little is known about the role of YAP1 and related genes in pancreatic cancer. Here, we identified target genes regulated by ...

2020年3月18日 · Our findings that YAP1 activation causes very early OSCC onset, and that loss of YAP1 prevents the appearance of these tumors, prompted us to theorize that YAP1 must be a potent oncogenic initiator of OSCC.

2021年7月1日 · YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling pathway. In addition to important functions in normal tissue homeostasis and regeneration, YAP1 has also prominent functions in cancer initiation, aggressiveness, metastasis, and therapy resistance.

YAP1 (Yes-associated protein; Hugo Nomenclature HGNC:16262), also known as YAP65, is the major downstream mediator of the mammalian Merlin/Hippo pathway. YAP1 was originally identified and named by its ability to associate with the SH3 domain of the tyrosine kinase YES1 (Yamaguchi Sarcoma viral oncogene homologue 1).