Identification of a novel YAP-14-3-3ζ negative feedback loop
2017年5月19日 · Growing evidence indicates that 14-3-3ζ and yes-associated protein (YAP) substantially promote tumorigenesis and tumor development. However, the regulatory …
Phosphorylation of 14-3-3ζ links YAP transcriptional activation to ...
2019年5月10日 · Here, we report that hypoxia disassembles 14-3-3ζ from YAP and thereby promotes YAP nuclear localization mediated by ERK2, which directly binds to the D-site of …
14-3-3σ regulation of and interaction with YAP1 in acquired
2016年4月5日 · In this study, we investigated the molecular mechanism of 14-3-3σ function in gemcitabine resistance and found that 14-3-3σ up-regulates YAP1 expression and then binds …
NLK的磷酸化抑制YAP-14-3-3-相互作用，并诱导其核定位。,EMBO …
2016年12月17日 · Here, we report that Nemo-like kinase (NLK) phosphorylates YAP at Ser128 both in vitro and in vivo, which blocks interaction with 14-3-3 and enhances its nuclear …
Phosphorylation by NLK inhibits YAP‐14‐3‐3 ... - EMBO reports
2016年12月15日 · Here, we report that Nemo‐like kinase (NLK) phosphorylates YAP at Ser128 both in vitro and in vivo, which blocks interaction with 14‐3‐3 and enhances its nuclear …
PNAS | 控制进出核的古老信号蛋白14-3-3调节乳腺癌进展关键分子 …
2022年11月4日 · 这项名为“14-3-3τ drives estrogen receptor loss via ERα36 induction and GATA3 inhibition in breast cancer”的研究发表在《Proceedings of the National Academy of Sciences》 …
文献解析|YAP/TAZ因子在保护白色脂肪细胞免于凋亡中的作用研究
2024年12月16日 · 为了探讨YAP（Yes-associated protein）和TAZ在白色脂肪细胞中的具体功能，研究者采用了高脂饲料喂养tamoxifen诱导的iAd-Yap/Taz-KO（诱导型脂肪细胞特异 …
yap1促进nsclc的增殖、侵袭及转移，促进了nsclc肿 瘤干细胞的更新及血管拟态，降低了NSCLC对化疗、放疗、表皮生长因子受体-酪氨酸激酶抑制剂（epidermalgrouthfactorrecep⁃
癌蛋白YAP1的研究进展 - pibb.ac.cn
Because hyperactivated YAP1 can promote the occurrence and progress of tumor, YAP1 was defined as an oncoprotein. Recently, researchers found that YAP1 variants were associated …
CircPAK1通过与14-3-3ζ相互作用调节YAP核定位促进肝细胞癌的进 …
2022年9月22日 · CircPAK1 通过与 YAP 竞争性结合 14-3-3 ζ 发挥其致癌功能，从而促进 YAP 核定位，导致 Hippo 信号通路失活。 外泌体 circPAK1 可能会导致对 lenvatinib 的耐药性，为 …