2021年5月1日 · We designed expression vectors encoding for the most-represented isoforms of YAP1 with either one or two WW domains and studied their specific signaling activities in YAP1 knock-out cell lines. YAP1 isoforms display both common and unique functions and activate distinct transcriptional programs, as the result of their unique protein interactomes.

YAP (Yes-associated protein) is a potent oncogene and a major effector of the mammalian Hippo tumor suppressor pathway. In this review, our emphasis is on the structural basis of how YAP recognizes its various cellular partners.

2015年8月21日 · Elevated activity of YAP1, a transcriptional coactivator and well-established oncogene has been reported to occur in human cancers. Comprehensive identification of YAP1 regulated genes and its mode of action will be of high importance to uncover YAP1 biology that could be exploited for a therapeutic intervention.

2024年12月25日 · YAP1 (Yes1 Associated Transcriptional Regulator) is a Protein Coding gene. Diseases associated with YAP1 include Coloboma, Ocular, With Or Without Hearing …

2021年7月1日 · In this review we are discussing the molecular functions of YAP1 and its roles in cancer, with a focus on the different mechanisms of de-regulation of YAP1 activity in human cancers, including inactivation of upstream Hippo pathway tumor suppressors, regulation by intersecting pathways, miRNAs, and viral oncogenes.

2025年1月18日 · TAZ (Transcriptional coactivator with PDZ-binding motif), a homolog of YAP1, shares many functional and structural similarities with YAP1. Given this, it is plausible that CK2α may regulate TAZ...

2013年1月1日 · Yes-associated protein 1 (YAP1) is a potent oncogenic protein and is one of the two main effectors of the Hippo tumor suppressor pathway. Originally, YAP1 cDNA was isolated by screening expression libraries for proteins that associate with SH3 domains of Yes and Src protein-tyrosine kinases.

YAP1 is a key mediator of the Hippo pathway capable of exerting a profound effect on organ size as well as tumorigenesis. Alternative mRNA splicing of human YAP1 results in at least 8 protein isoforms that differ within the 2nd WW motif and the ...

2020年6月1日 · YAP consists of several motifs and domains. The N-terminal includes a proline-rich region (P-rich) followed by TEAD binding region. In the middle there are two tandem WW domains that bind to PPXY-motif-containing transcription factors, a Src homology domain 3 binding motif (SH3 BM), and a coiled-coil domain (CC).

2024年8月18日 · The activation of yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ) has been implicated in both regeneration and tumorigenesis, thus representing a double-edged sword in tissue homeostasis.