ROCK1 mechano-signaling dependency of human malignancies
2022年2月4日 · We demonstrate that p53 DNA contact mutants in human tumors, indirectly hyperactivate RhoA/ROCK1/actomyosin signaling, which is both necessary and sufficient to drive oncogenic TEAD/YAP...
YAP regulates cell mechanics by controlling focal adhesion assembly
2017年5月15日 · Here we unveil the molecular mechanism by which cell spreading and RhoA GTPase activity control FA formation through YAP to stabilize the anchorage of the actin cytoskeleton to the cell membrane....
RhoA/ROCK-YAP/TAZ Axis Regulates the Fibrotic Activity in
2021年9月6日 · Mechanistically, RhoAG14V induced the expression and nuclear translocation of YAP/TAZ to produce CTGF. Moreover, inhibition of ROCK or YAP decreased the expression of Collagen I and α-SMA proteins induced by DEX or RhoAG14V in HTM cells.
YAP1 is a potent driver of the onset and progression of oral
2020年3月18日 · Our findings that YAP1 activation causes very early OSCC onset, and that loss of YAP1 prevents the appearance of these tumors, prompted us to theorize that YAP1 must be a potent oncogenic initiator of OSCC.
YAP1 Recognizes Inflammatory and Mechanical Cues to …
YAP1 silencing suppresses cell survival by decreasing cell proliferation and increasing apoptosis, and alleviates fibrosis by reversing epithelial-mesenchymal transition (EMT) and extracellular matrix (ECM) deposition in prostatic BPH-1 and WPMY-1 cells.
Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK…
2024年12月3日 · By integrating functional and molecular studies in mouse and human BCa models, we show that NUMB loss leads to the upregulation of RHOA/ROCK signaling to the actin cytoskeleton. This, in turn,...
Fluid shear stress activates YAP1 to promote cancer cell motility
WSS dictates expression of a network of YAP1 effectors with executive roles in invasion, chemotaxis and adhesion downstream of the ROCK–LIMK–cofilin signalling axis. Altogether, these data implicate YAP1 as a fluid mechanosensor that functions to regulate genes that promote metastasis.
Elevated BMP and mechanical signaling through YAP1/RhoA …
Our results establish RhoA and YAP1 signaling as modulators of mechanotransduction in FOP and suggest that aberrant mechanical signals, combined with and as a result of the increased BMP pathway signaling through mutant ACVR1, lead to misinterpretation of the cellular microenvironment and a heightened sensitivity to mechanical stimuli that promo...
从皮肤入手揭开类器官干细胞自组织机制的秘密 - 知乎
激活的 Yap1 诱导基底细胞中的 Wnt 和 MMP（表皮执行器）以促进细胞流动，允许表皮细胞从 CMU 中伸出。 真皮细胞表达的 Rock（真皮执行器）在两个 CMU 之间产生刚性力桥，并通过激活层粘连蛋白和 β1- 整合素 加速组织混合。
科学网—Nature Cell Biology | YAP融合蛋白凝聚体通过转录调控驱 …
2024年5月25日 · 体内、体外实验均证实， yap1-mamld1和c11orf95-yap1融合蛋白具有强致瘤性，并且形成的室管膜瘤特征与人类相似。 作者通过在细胞及肿瘤组织样本中观察 YAP1-MAMLD1和C11ORF95-YAP1融合蛋白定位发现，其在核仁具有明显的点状定位。