YAP/TAZ upstream signals and downstream responses
2018年7月26日 · We review how the transcriptional regulators YAP and TAZ integrate mechanical cues with the response to soluble signals and metabolic pathways to control multiple aspects …
Analysis of Yes-Associated Protein-1 (YAP1) Target Gene
2022年3月31日 · YAP1 transcriptionally regulates the expression of genes that drive the oncogenic phenotypes. Here, we assess a potential YAP target gene signature to predict a …
Gene Set - YAP1 - maayanlab.cloud
2212 target genes of the YAP1 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. Search for genes and …
The YAP1–NMU Axis Is Associated with Pancreatic Cancer …
Here, we identified target genes regulated by YAP1 and explored their role in pancreatic cancer progression and the related clinical implications. Analysis of different pancreatic cancer …
YAP1 and its fusion proteins in cancer initiation, progression and ...
2021年7月1日 · Prominent YAP1-TEAD target genes include CTGF, CYR61, NPPB, CCND1, AXL, DKK1, ITGB2, WWC1, AMOTL2 and ANKRD1 (Stein et al., 2015; Wang et al., 2018). …
YAP1 Exerts Its Transcriptional Control via TEAD-Mediated ... - PLOS
2015年8月21日 · Here we investigated its genomic binding landscape in YAP1-activated cancer cells, as well as in non-transformed cells. We demonstrate that TEAD transcription factors …
YAP1 Yes1 associated transcriptional regulator [Homo sapiens …
2025年3月26日 · YAP1 Is Involved in Tumorigenic Properties of Prostate Cancer Cells. Collak FK, et al. Pathol Oncol Res, 2020 Apr. PMID 30859486. Yes-associated protein (YAP) modulates …
Hyperactivated YAP1 is essential for sustainable progression of …
4 天之前 · We found that YAP1 and its primary target genes are frequently upregulated in ccRCC and the upregulation of these genes is associated with unfavorable patient outcomes. …
靶向YAP/TAZ信号通路改善肿瘤免疫治疗的研究进展 - PMC
研究发现肝癌组织中yap1与自噬标志物lc3b表达呈正相关（r=0.31, p<0.001）。同时抗pd-1治疗会激活yap1通路并提升lc3b表达，提示其参与免疫耐药。通过联合yap1敲除与抗pd-1治疗，可使 …
A highly sensitive reporter system to monitor endogenous YAP1…
2024年8月18日 · To obtain a highly sensitive YAP1/TAZ/TEAD-responsive reporter gene applicable to various human cells, we generated a hygromycin-selective lentiviral reporter …
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