The deubiquitinase USP9X promotes tumor cell survival and …
2018年2月16日 · Here we demonstrate that the deubiquitination enzyme USP9X deubiquitinates and stabilizes YAP1, thereby promoting cancer cell survival. Increased USP9X expression …
Macrophage K63-Linked Ubiquitination of YAP Promotes Its …
2020年8月4日 · Tumor necrosis factor receptor-associated factor 6 (TRAF6), a downstream effector of interleukin-1β (IL-1β), triggers YAP ubiquitination at K252, which interrupts the …
Nuclear condensates in YAP1-driven ependymoma - Nature
2023年2月2日 · In supratentorial hemispheric YAP1–MAMLD1 fusion-positive ependymoma (ST-EPN-YAP1) stem cells, YAP fusion proteins form nuclear condensates through NLS-mediated …
OTUB1 suppresses Hippo signaling via modulating YAP protein in …
2022年10月21日 · We discovered OTUB1 as a critical factor to facilitate gastric cancer cell stemness and progression, which deubiquitinated and stabilized YAP protein. The clinical data …
STUB1 suppresseses tumorigenesis and chemoresistance through ...
2019年8月8日 · Here we report that the E3 ubiquitin ligase STUB1 ubiquitinates and destabilizes YAP1, thereby inhibiting cancer cell survival. Low levels of STUB1 expression were correlated …
USP14 inhibition by degrasyn induces YAP1 degradation and …
2025年2月1日 · Mechanistically, we found that USP14 could interact with Yes-associated protein 1 (YAP1) and induce its deubiquitination in radioresistant ESCA cells. Interestingly, we …
USP10通过去泛素化和稳定YAP/TAZ促进肝细胞癌的增殖 - 知乎
2023年8月2日 · 在这项研究中，作者全面分析了去泛素化酶 (DUB) 对肝细胞癌模型中YAP/TAZ转录活性和蛋白质丰度的贡献，并确定了泛素特异性肽酶10 (USP10) 作为有效的YAP/TAZ激 …
TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate …
2016年7月7日 · We find that RASSF1A expression regulates TGF-β-induced YAP1/SMAD2 interaction and leads to SMAD2 cytoplasmic retention and inefficient transcription of TGF-β …
癌蛋白YAP1的研究进展 - pibb.ac.cn
Because hyperactivated YAP1 can promote the occurrence and progress of tumor, YAP1 was defined as an oncoprotein. Recently, researchers found that YAP1 variants were associated …
Yap1过表达在非小细胞肺癌（non-smallcelllung cancer，NSCLC）、肝细胞肝癌、胃癌、结直肠癌、小细胞 肺癌等多种肿瘤中是预后差的标志[10]。在临床前研究 中，抑制Yap1可减少肿瘤 …