14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene. [5] This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine -containing proteins.

2024年12月25日 · YWHAE (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon) is a Protein Coding gene. Diseases associated with YWHAE include Endometrial Stromal Sarcoma and Kidney Clear Cell Sarcoma.

The YWHAE gene provides instructions for making the 14-3-3 epsilon protein, which is part of the large 14-3-3 protein family. Learn about this gene and related health conditions.

2024年1月26日 · 14–3-3ε, a member of the 14–3-3 protein family, is encoded by the YWHAE gene. In humans, YWHAE is located on the 17 th chromosome and involved in cell adhesion, cell cycle regulation, signal transduction, and other biological processes.

5 天之前 · YWHAE is closely related to several human diseases and acts as a molecular scaffold for malignant transformation. However, whether YWHAE promotes HB development remains unknown. Conducting RNA and ...

Results: We report a series of 10 individuals with heterozygous loss-of-function YWHAE variants (3 single-nucleotide variants and 7 deletions <1 Mb encompassing YWHAE but not PAFAH1B1), including 8 new cases and 2 follow-ups, added with 5 …

YWHAE (14-3-3ε) protein levels are considered to be a reliable biomarker for neurodegeneration. The YWHAE protein interacts both directly and indirectly with human immunodeficiency virus (HIV) accessory proteins, leading to cell death.

YWHAE expression was associated with tumor size, lymph node metastasis, and poor patient survival in patients with breast cancer. YWHAE overexpression significantly increased the proliferation, migration, and invasion abilities of breast cancer cells.

2016年12月20日 · YWHAE may act as a negative regulator of the cyclin CDC25B, which is a transcriptional target of MYC oncogene. The understanding of YWHAE role and its targets is important for the better knowledge of gastric carcinogenesis.

results support YWHAE being a risk gene for Major Depressive Disorder in the Han Chinese population. YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells.

YWHAE is a prognostic marker in Breast invasive carcinoma, Kidney renal clear cell carcinoma, Lung adenocarcinoma

2022年10月10日 · Here, we report clinical manifestations of 15 patients with clear dose-dependent loss-of-function variants in YWHAE, 5 of which are patients with variants affecting only YWHAE showing developmental and speech delays (5 of 5) as well as brain malformations (4 of 4), establishing YWHAE as a gene causing a rare neurodevelopmental disease.

The YWHAE gene provides instructions for making the 14-3-3 epsilon protein, which is part of the large 14-3-3 protein family. Proteins in this family attach (bind) to other proteins that are involved in cell signaling. Proteins in the 14-3-3 family either turn on ( …

2022年1月28日 · To understand the relationship between YWHAE, NUTM2A, and NUTM2B gene rearrangement/fusion and malignant tumor, YWHAE-FAM22 fusion gene/translocation and tumor, YWHAE gene polymorphism and mental illness, as well as the relationship between 17p13.3 region change and disease occurrence.

2025年2月8日 · The protein YWHAE (14-3-3 epsilon) in spermatozoa is essential for male fertility. Activation of innate immunity by 14-3-3 epsilon, a new potential alarmin in osteoarthritis. Rod photoreceptors are enriched in YWHAE (14-3-3 epsilon).

2024年5月13日 · YWHAE overexpression significantly reduced the expression level of SCN5A mRNA and sodium current density, whereas YWHAE knockdown significantly increased SCN5A mRNA expression and sodium current density in HEK293/Na V 1.5 and H9c2 cells.

Interestingly, the strongest evidence for epistasis was detected for the YWHAE gene, whose product, 14‐3‐3ϵ, is known to mainly form heterodimers with many other 14‐3‐3 proteins. YWHAE revealed possible interaction with YWHAZ and YWHAQ in association with adult ADHD (Table I).

2024年11月27日 · Comprehensive analysis of the function of helicobacter-associated ferroptosis gene YWHAE in gastric cancer through multi-omics integration, molecular docking, and machine learning.

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