2020年，Yang等人报道了一种通过有机 SOMO催化 的对映选择性醛-烷基化/半频那醇重排(Scheme 2)。该方法使用手性伯胺(C1)作为有机催化剂，Fe(phen)3(PF6)3作为氧化剂。

2025年1月17日 · Singly occupied molecular orbital (SOMO) activation of in situ generated enamines has achieved great success in (asymmetric) α-functionalization of carbonyl compounds. However, examples on the use of this activation mode in the transformations of other functional groups are rare, and the combination of SOMO activation with transition metal ...

2016年3月31日 · The low-lying singly occupied molecular orbitals (SOMOs) of all the PCs are similar, with the electron localized over the phenazine π system. For PCs 1 (OMe) and 2 (H), the high-lying SOMO is also localized on the phenazine rings; in contrast, for 3 (CF 3 ) and 4 (CN), the high-lying SOMO, occupied by the reducing e – , resides on the phenyl ...

本文则是光催化结合somo活化，即光催化剂取代单电子氧化剂用于生成生成somo体！ 之前的SOMO活化需要两当量单电子氧化剂，第二当量用于氧化最后的自由基到碳正离子。

2010年4月14日 · 第一个有机催化对映选择性自由基多环化是使用单占据分子轨道（SOMO）催化完成的。 该策略依赖于多烯醛与咪唑烷酮催化剂、使用合适的铜 (II)氧化剂缩合形成的手性烯胺的选择性单电子氧化。 该反应在室温弱酸性条件下进行，并显示出与一系列贫电子和富电子官能团的相容性。 通过自由基芳基化终止，随后进行氧化和重新芳构化，得到一系列多环醛（12个实例，54-77％产率，85-93％ee）。 描述了在单个催化剂控制的级联中最多六个新碳环的对映选择 …

2007年5月12日 · The first enantioselective organocatalytic α-enolation of aldehydes has been accomplished using singly occupied molecular orbital (SOMO) catalysis. Chiral secondary amines react with aldehydes to form transient enamines that undergo selective one-electron oxidation to generate electrophilic radical cations.

occupied molecular orbital (SOMO) catalysis, thereby paving the way for exploring new possibilities of asymmetric radical chemistry. Furthermore, the rapid strides in photochemistry and electrochemistry have rejuvenated radical chemistry, bringing forthmoresophisticatedandrefinedstrategies.Thecombinationoforganocatalysis

2011年8月1日 · The intramolecular asymmetric cyclization of aldehydes has been accomplished using singly occupied molecular orbital (SOMO) catalysis. Selective oxidation of chiral enamines (formed by the condensation of an aldehyde and a secondary amine catalyst) leads to the formation of a 3π-electron radical species.

该不对称合成方法学基于小分子催化SOMO活化的策略，实现了醛α位亲核性碳原子通过极性反转参与的semipinacol重排反应，进一步拓展了碳亲电试剂促进的该类重排反应。

2010年3月24日 · The first organocatalytic enantioselective radical polycyclization has been accomplished using singly occupied molecular orbital (SOMO) catalysis. The presented strategy relies on a selective single-electron oxidation of chiral enamines formed by condensation of polyenals with an imidazolidinone catalyst employing a suitable copper(II) oxidant.