2009年2月15日 · Histone lysine methylation is an important epigenetic mark that regulates gene expression and chromatin organization. G9a and G9a-like protein (GLP) are euchromatin-associated methyltransferases...

2011年11月15日 · We find that the amino-terminal lysine 44 of mouse Dnmt3a (equivalent to lysine 47 of human DNMT3A) is dimethylated by G9a/GLP. We also find that the resulting modification (Dnmt3aK44me2) is...

Here we present the crystal structure of the catalytic SET domain of GLP in complex with BIX-01294 and S-adenosyl-L-homocysteine. The inhibitor is bound in the substrate peptide groove at the...

2010年7月2日 · We applied the concept of adding a lysine mimic to an established inhibitor (BIX-01294) of histone H3 lysine 9 methyltransferases G9a and G9a-like protein by including a 5-aminopentyloxy moiety, which is inserted into the target lysine-binding channel and becomes methylated by G9a-like protein, albeit slowly.

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We present the crystal structure of the catalytic SET domain of G9a-like protein (GLP) in complex with BIX-01294. The inhibitor is bound in the substrate peptide groove at the location where the histone H3 residues (Lys4 to Arg8) N-terminal to the target lysine would occupy.

Chang, Yanqi ; Ganesh, Thota ; Horton, John R. et al. / Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. In: Journal of Molecular Biology . 2010 ; Vol. 400, No. 1. pp. 1-7.

Here we reveal an interplay between monomethylation of DNMT1 Lys142 by SET7 and phosphorylation of DNMT1 Ser143 by AKT1 kinase. These two modifications are mutually exclusive, and structural analysis suggests that Ser143 phosphorylation interferes with Lys142 monomethylation.

My research lies at the intersection of applied mathematics and machine learning for large-scale real-world problems. In particular, I am interested in designing novel knowledge-driven and data-driven models to solve inverse problems, with areas of interest including optimisation, machine learning, and mathematical modelling.

Professor is working and performing all researches currently with China Agricultural University on related studies of Biology and agricultural science.