Targeting the retinoid signaling pathway with YCT-529 for
2025年3月13日 · After single dose administration of YCT-529 (10 mg/kg in saline), YCT-529 rapidly accumulated in the systemic plasma with peak levels (C max) of 907 ng/ml or 2 µM …
What We Know About The Male Birth Control Pill YCT-529 Tested …
2023年12月14日 · Unlike the female birth control pill, YCT-529 is a hormone-free type of retinoic acid receptor-alpha (RAR-alpha) inhibitor, which means it works by blocking access to vitamin …
YourChoice Therapeutics Begins Second Human Study for
2024年9月24日 · The phase 1b/2a study will examine multiple ascending doses (MAD) of YCT-529 in up to 50 male volunteers aged 28-70 to determine tolerability and effect on sperm …
YourChoice doses participants in trial of birth control pill for men
2024年9月25日 · YourChoice Therapeutics has dosed the first cohort of male subjects in a Phase Ia/IIb clinical trial of YCT-529, a hormone-free male birth control pill. The trial will assess the …
YourChoice Therapeutics Completes Phase 1a Clinical Study ... - BioSpace
2024年6月3日 · YCT-529 is a retinoic acid receptor-alpha (RAR-alpha) inhibitor, which prevents sperm production by blocking access to vitamin A in the testes. Researchers discovered this …
YCT529 (YCT529) - 药物靶点：RARα_在研适应症：避孕_专利_临 …
yct-529是一种视黄酸受体-α（rar-a）抑制剂，通过阻断rar-α来阻止睾丸中精子的产生和释放。 临床前研究表明，YCT-529在预防小鼠妊娠方面有99%的有效性，且100%可逆。
Development of the retinoic acid receptor alpha-specific antagonist YCT …
2025年1月3日 · The search for RARα-specific antagonists led to the development of YCT-529, a potent and selective RARα antagonist with favorable pharmacokinetics. YCT-529 …
YCT-529 在 男性避孕-临床试验注册中心-ICH GCP
2024年7月3日 · 这是 YCT-529 在健康男性中进行的一项 1b/2a 期、多中心、开放标签、28 天重复剂量递增研究，旨在评估安全性、耐受性、PK 和 PD，并评估性功能和情绪。 队列将在禁食 …
Male Birth Control Pill Enters Human Clinical Trials - Technology …
1 天前 · The new drug, called YCT-529, is a first-in-class, hormone-free and orally administered male contraceptive. Developed in collaboration with Columbia University in New York and …
Hormone-free male birth control pill undergoing clinical trials ...
1 天前 · The drug, called YCT-529, was 99% effective within four weeks in preventing pregnancies in mice trials, according to the University of Minnesota. YCT-529 lowered sperm …
- 某些结果已被删除