Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is a secreted glycoprotein that is approximately 40k Da in size that in humans is encoded by the CHI3L1 gene. [5][6][7] The name YKL-40 is derived from the three N-terminal amino acids present on the secreted form and its molecular mass.

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2024年2月15日 · YKL-40 or Chitinase-3-Like Protein 1 (CHI3L1) is a highly conserved glycoprotein that binds heparin and chitin in a non-enzymatic manner. It is a member of the chitinase protein family 18, subfamily A, and unlike true chitinases, YKL-40 is a chitinase-like protein without enzymatic activity for chitin.

YKL-40 is a biomarker for inflammatory diseases’ diagnosis and prediction. YKL-40 concentration increases with age and has variations in healthy population. YKL-40 is convincing in pancreatic/liver disease, arthritis, bronchitis, and sepsis. YKL-40 is debatable in cardiovascular/neurological/renal disease, diabetes, asthma.

2021年4月4日 · YKL-40 levels were found to be elevated in patients with ILD, but these results are inconsistent. Therefore, we conducted a systematic review and meta-analysis to accurately study the relation between YKL-40 and ILD.

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2019年1月14日 · 人类软骨糖蛋白39（YKL-40）是一种分子量高达 40kDa 的糖蛋白，可由不同类型细胞生成和分泌，如内皮细胞和免疫细胞等。 既往研究还发现 YKL-40在细胞粘附、血管平滑肌细胞迁移、内皮细胞血管生成信号通路活化方面有着促进作用，并参与多种炎症进程，包括动脉粥样硬化和内皮功能紊乱等。 然而，YKL-40 和 HD患者死亡以及心血管事件风险之间的关系尚不明确。 该研究分析了多中心前瞻性观察研究-终末期肾病风险分层研究（ISAR）的相关数据，旨 …