YME1L1 consists of 716 amino acids and is highly similar to all mitochondrial AAA proteases and in particular to yeast Yme1p. Three different domains are identified via sequence analysis, including an AAA consensus sequence between amino acids 317 and 502, an ATP/GTP binding motif, and a HEXXH motif typical of a zinc -dependent binding domain. [7]

2024年12月25日 · YME1L1 (YME1 Like 1 ATPase) is a Protein Coding gene. Diseases associated with YME1L1 include Optic Atrophy 11 and Autosomal Recessive Isolated Optic Atrophy. Among its related pathways are Cellular responses to stimuli and …

线粒体蛋白酶Yme1L是由核编码然后输入定位到线粒体的ATP 依赖性的蛋白酶，它是线粒体内膜中线粒体蛋白质量调控的重要蛋白，其很多生物学功能特别是在线粒体动力学中的功能和作用机制还很不清楚。

近年来研究发现，定位于线粒体内膜的i-AAA蛋白酶YME1L能通过调节OPA1实现对线粒体融合和分裂的控制，其缺失会导致细胞代谢异常。 然而，YME1L在线粒体蛋白稳态调控中的作用仍不甚清楚。 2019年11月7日，来自德国马克思-普朗克生物衰老研究所的Thomas Langer教授（德国科学院院士）带领的团队在Nature杂志发表了题为Lipid signalling drives proteolytic rewiring of mitochondria by YME1L的文章，揭示了mTORC1-LIPIN1-YME1L轴是代谢-线粒体动态平衡这 …

2019年11月6日 · YME1L degrades mitochondrial protein translocases, lipid transfer proteins and metabolic enzymes to acutely limit mitochondrial biogenesis and support cell growth....

2014年3月17日 · Constitutive OPA1 cleavage by YME1L and OMA1 at two distinct sites leads to the accumulation of both long and short forms of OPA1 and maintains mitochondrial fusion. Stress-induced OPA1 processing by OMA1 converts OPA1 completely into short isoforms, inhibits fusion, and triggers mitochondrial fragmentation.

近年来研究发现，定位于线粒体内膜的i-AAA蛋白酶YME1L能通过调节OPA1实现对线粒体融合和分裂的控制，其缺失会导致细胞代谢异常 【2】。 然而，YME1L在线粒体蛋白稳态调控中的作用仍不甚清楚。 2019年11月7日，来自德国马克思-普朗克生物衰老研究所的Thomas Langer教授（德国科学院院士）带领的团队在Nature杂志发表了题为Lipid signalling drives proteolytic rewiring of mitochondria by YME1L的文章，揭示了mTORC1-LIPIN1-YME1L轴是代谢-线粒体动态平衡这 …

2024年5月20日 · YME1L silencing impaired mitochondrial functions in osteosarcoma cells, causing mitochondrial depolarization, oxidative injury, lipid peroxidation and DNA damage as well as mitochondrial...

2025年1月4日 · YME1L1 was identified as the first NUMT (nuclear mtDNA) suppressor gene in human and demonstrate that inactivation of YME1L1 induces migration of mtDNA to the nuclear genome.

2020年5月26日 · The i-AAA protease YME1L, an ATP-dependent proteolytic complex in the mitochondrial inner membrane, coordinates mitochondrial biogenesis and dynamics with the metabolic output of mitochondria. mTORC1-dependent lipid signaling drives proteolytic rewiring of mitochondria by YME1L.