2016年4月7日 · Overall, our results showed that the caspase-1 inhibitor AC-YVAD-CMK protected against acute gastric injury in mice by affecting the NLRP3 inflammasome and attenuating inflammatory processes and apoptosis. This was similar to the mechanism associated with NF-κB and P38 mitogen-activated protein kinase signalling pathways.

The SARS-CoV-2 N protein promotes NLRP3 inflammasome activation and generates excessive inflammatory responses, which are blocked by Ac-YVAD-cmk . AI-44 and FC11A-2 AI-44, a curcumin analogue, binds to peroxiredoxin 1 (PRDX1) and promotes the interaction of PRDX1 with pro-caspase-1, thereby demonstrating an association between pro-caspase-1 and ...

这项研究是在患有二硝基苯磺酸（DNBS）引起的结肠炎的大鼠中进行的，旨在研究与不可逆抑制剂（INF39）直接阻断NLRP3炎症小体与Ac-YVAD-cmk（YVAD，caspase-1抑制剂）和anakinra（ IL-1β受体拮抗剂），在下 游作用于NLRP3信号传导。

2023年5月1日 · Caspase-1 inhibitor (Ac-YVAD-cmk) and primary adipocytes from NLRP3 and caspase-1 knockout mice were utilized to block NLRP3 inflammasome activation. Biomarkers were measured by using real-time PCR, western blotting, immunofluorescence staining, and enzyme assay kits.

2020年7月23日 · Targeting NLRP3 and caspase-1, the executor of pyroptosis, with selective inhibitors MCC950 and Ac-YVAD-cmk treatment significantly prevented microglial pyroptosis, reduced infiltration of leukocytes, improved neurologic outcome, and alleviated neuro-pathological damages after cardiac arrest in modeling rats.

2018年4月17日 · Known as one of the innate immune sensors, the NOD-like receptor protein 3 (NLRP3) inflammasome composes of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1. This inflammasome regulates caspase-1 activation that controls the maturation and secretion of IL-1β and IL-18 [17, 18, 19].

2023年8月24日 · Blocking the NLRP3 inflammasome pathway with the caspase-1 specific inhibitor AC-YVAD-CMK prevents motor and cognitive impairments in HIBD models. These findings establish a scientific foundation for the development of NLRP3 inflammasome pathway inhibitors, such as AC-YVAD-CMK, as potential therapeutic interventions to …

By using MCC950 and Ac-YVAD-cmk, two highly selective inhibitors targeting NLRP3 and caspase-1, respectively, we aim to demonstrate the therapeutic effect of alleviating pyroptosis on TMJ synovial inflammation reaction.

2018年1月15日 · NLRP3 inflammasome inhibition by short hairpin RNA (shRNA)-mediated knockdown of NLRP3, selective inhibitor MCC950, and caspase-1 inhibitor Z-YVAD-FMK attenuated silica-induced EMT. Western blot analysis indicated that TAK1-MAPK-Snail/NF-κB pathway involved NLRP3 inflammasome-mediated EMT.

Western blot结果提示球囊损伤+ AC-YVAD-CMK组中NLRP3蛋白表达较球囊损伤组显著降低（P = 0.009）；cleaved-Caspase-1蛋白在三组中的表达趋势与NLRP3蛋白表达一致（P = 0.000）。且球囊损伤+ AC-YVAD-CMK 组大鼠的促炎性细胞因子IL-1β和IL-18 水平较球囊损伤组显著降 …