The14-3-3 protein zeta/delta (14-3-3ζ) is a protein (in humans encoded by the YWHAZ gene on chromosome 8) with an important apoptotic constituents.

2024年12月25日 · YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta) is a Protein Coding gene. Diseases associated with YWHAZ include Autosomal Dominant Non-Syndromic Intellectual Disability and Otitis Media. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Activation of cAMP-Dependent PKA.

2023年7月14日 · We demonstrated that functional activation of Ywhaz by the gene search vector led to enhanced metastatic capability in mouse pancreatic cancer cells. The metastasis-promoting role of YWHAZ was...

2022年5月2日 · Genetic variants in YWHAZ contribute to psychiatric disorders such as autism spectrum disorder and schizophrenia, and have been related to an impaired neurodevelopment in humans and mice. Here,...

YWHAZ (also named 14-3-3ζ) is a central hub protein for many signal transduction pathways and plays a significant role in tumor progression. Accumulating evidences have demonstrated that YWHAZ is frequently up-regulated in multiple types of cancers ...

2023年8月22日 · 近日，来自北京大学肿瘤医院与研究所的研究者们在Cell Death and Disease杂志上发表了题为“High-throughput functional screen identifies YWHAZ as a key regulator of ...

2022年5月12日 · YWHAZ基因与自闭症和精神分裂症等精神疾病和神经系统疾病有关。 这项研究使用斑马鱼作为动物模型,由专家Noelia Fernandez-Castillo Bru Cormand,学院的成员大学的生物学和生物医学研究所的巴塞罗那 (北京市教委),桑特琼德德吴研究所 (IRSJD)和罕见疾病网络生物医学中心 (CIBERER),以及来自英国莱斯特大学的威廉·h·j·诺顿。 其他合作者包括来自UB神经科学研究所 (UBNeuro)、光子科学研究所 (ICFO)和理研脑科学中心 (CBS，日本)的专家。 YWHAZ基 …

The results suggest that YWHAZ is the most suitable as the reference gene in human mononuclear leukocytes. YWHAZ is upregulated in ovarian cancers in contrast to normal tissues. High YWHAZ expression was found to be associated with TNM stage and metastasisfree prognosis of ovarian cancer patients.

2020年2月3日 · ywhaz（也称为14-3-3ζ）是许多信号转导途径的中心枢纽蛋白，在肿瘤进展中起重要作用。 越来越多的证据表明，YWHAZ在多种类型的癌症中经常被上调，并在多种细胞活动中充当致癌基因，包括细胞生长，细胞周期，细胞凋亡，迁移和侵袭。

利用这一策略，研究者确定YWHAZ是胰腺癌转移的关键调节因子。研究者证明了基因搜索载体对Ywhaz基因的功能性激活导致了小鼠胰腺癌细胞转移能力的增强。YWHAZ的转移促进作用在人胰腺癌细胞中得到进一步验证。