Nonbenzodiazepines (/ ˌnɒnˌbɛnzoʊdaɪˈæzɪpiːn, - ˈeɪ -/ [1][2]), sometimes referred to colloquially as Z-drugs (as many of their names begin with the letter "z"), are a class of psychoactive, depressant, sedative, hypnotic, anxiolytic drugs that are benzodiazepine-like in uses, such as for treating insomnia [3] and anxiety. [4]

2024年3月6日 · Prescription Z-drugs work by slowing activity in the brain. Used properly, they can help you sleep. Quality sleep can have a positive impact on physical and mental health. But the treatments...

非苯二氮平類藥物 （nonbenzodiazepine），其中三種俗稱 Z類藥物 （Z-drugs）是一類藥理作用與 苯二氮平類藥物 （BZD）類似的藥物， [1] 主要用於治療失眠，效果和苯二氮類藥物相當接近。 Z類藥物由三種z開頭的物質組成： 唑匹可隆 （zopiclone）、 唑吡坦 （zolpidem）和 扎來普隆 （英語：Zaleplon） （zaleplon）。 這三種物質和BZD結合的位點一樣，都是GABA-A受體的BZD旁結合位。 [2] 可產生 身體依賴，產生的戒斷反應和苯二氮平類接近。 [3][4][5] 不能通過 …

2023年9月13日 · Z-drugs, such as zolpidem (Ambien), are non-benzodiazepines that start with the letter “Z.” Truth be told, these substances are more notable because they’re often taken to treat insomnia — in other words, to catch some Zs (sleep).

2017年7月1日 · Understanding the risks and benefits of insomnia medications is critical. Controlled-release melatonin and doxepin are recommended as first-line agents in older adults; the so-called z-drugs...

one和eszopiclone等成分,因此又俗稱為Z-drugs。此兩類藥品用於治療失眠的藥理機轉相似,主要作用於中樞神經系統GABA A受體複合體,進而調控氯離子通道的開啟, 抑制神經元刺激,達到鎮靜、安眠的效果。相較於BZD類藥品,部分Z-drug類藥品(例如zolpidem)對於GABA A受體的α1亞基具有選擇性,因此較. 少有肌肉放鬆、抗焦慮及抗痙攣的效果1。此外,Z-drug類藥品作用迅速、半衰期短等優點也讓它�. 為近年來最常用於鎮靜安眠的藥品之一。目前我國經衛生福利部食品藥物管理 …

Which Drugs are “Z-drugs” or “Nonbenzodiazepines”? The Z-drugs are typically prescribed for insomnia. In addition to carrying the same risks of physiological dependence and protracted withdrawal as benzodiazepines, these drugs have been shown to cause bizarre or dangerous sleep behavior, such as driving or cooking while asleep.

非苯二氮卓类药物是一种相对较新的催眠药。该类药物也称为“Z”类药物，包括唑吡坦、佐匹克隆、扎来普隆和右佐匹克隆（zolpidem, zopiclone, zaleplon, and eszopiclone）。 这些药物在结构上与 [1]不同，因为它们…

2022年10月23日 · Z-drugs, otherwise known as benzodiazepine receptor agonists, are used to help patients with insomnia that is associated with difficulty falling asleep (sleep latency), difficulty staying asleep (sleep maintenance), or not feeling rested after a night’s sleep (sleep quality).

"Z类药物 (Z-drugs)"是唑吡坦、佐匹克隆/右佐匹克隆和扎来普隆的统称,属于非苯二氮 类催眠药物。 本文将综述Z类药物的药理学特性以及发生滥用和依赖的潜在机制、流行病学特征、临床表现和干预措施,揭示此类药物一旦超过指南推荐使用的剂量和疗程,发生依赖和滥用的风险就会增加。 临床医生应提高对Z类药物滥用和依赖风险的警惕。...