2019年4月4日 · ZEB1 can regulate cytokine expression from cDC1s upon activation with CpG. ZEB1 and ZEB2 can play reciprocal roles in CD8 + T cells. ZEB1 and ZEB2 are zinc-finger E homeobox-binding transcription factors best known for their role in driving epithelial to mesenchymal transition.

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site. [7][6] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc ...

2024年3月22日 · We identified and validated ZEB1 binding peaks in the promoter of key lineage-specific genes crucial for melanoma cell identity. Mechanistically, ZEB1 negatively regulates SOX10-MITF dependent...

ZEB1 and ZEB2 are zinc-finger E homeobox-binding transcription factors best known for their role in driving epithelial to mesenchymal transition. However, in recent years our understanding of these two transcription factors has broadened, and it is now clear that they are expressed by a …

2023年10月20日 · Our data identify a Zeb1-miR-96/182-Cybb regulatory axis that controls cross-presentation in cDC1 and uncover an essential role of Zeb1 in cDC1 homeostasis and function.

2021年8月24日 · Genetic deletion of Zeb1 causes a shift toward symmetric cell division that consumes the RGL cell and generates pro-neuronal progenies, resulting in an increase of newborn neurons and a decrease of newly generated astrocytes. We identify ZEB1 as positive regulator of the ets-domain transcription factor ETV5 that is critical for asymmetric division.

Zinc finger E-box binding homeobox 1 (ZEB1) is a master modulator of the epithelial–mesenchymal transition (EMT), a process whereby epithelial cells undergo a series of molecular changes...

2024年12月25日 · ZEB1 (Zinc Finger E-Box Binding Homeobox 1) is a Protein Coding gene. Diseases associated with ZEB1 include Corneal Dystrophy, Fuchs Endothelial, 6 and Corneal Dystrophy, Posterior Polymorphous, 3. Among its related pathways are Cytokine Signaling in Immune system and ERK Signaling.

Both ZEB1 and ZEB2 can bind Zp via the ZV element. In EBV-positive cells containing only ZEB1, knockdown of ZEB1 led to viral reactivation out of latency, with synthesis of EBV immediate-early and early lytic gene products.

2020年3月19日 · Zinc finger E-box binding homeobox 1 (ZEB1) is a prime element of a network of transcription factors controlling EMT and has been identified as an important molecule in the regulation of DNA damage, cancer cell differentiation, and metastasis. Recent studies have considered upregulation of ZEB1 as a potential modulator of chemoresistance.