ZONAB 结合于ZO-1 的SH3(Src homology 3)结构域, 并与多种调控细胞周期的基因、蛋 白质、酶 、转 录因子等相互作用, 共同构成ZO-1/ZONAB信号通路。 研究证实, ZO-1/ZONAB 信号通路 …
The Unique-5 and -6 Motifs of ZO-1 Regulate Tight Junction …
ZO-1 contains a conserved SH3-GUK module that is separated by a variable region (unique-5), which in other MAGUKs has proven regulatory functions. To identify motifs in ZO-1 critical for …
CDD Conserved Protein Domain Family: SH3_ZO-1
2020年10月2日 · The SH3 domain of ZO-1 has been shown to bind ZONAB, ZAK, afadin, and Galpha12. SH3 domains are protein interaction domains that bind to proline-rich ligands with …
The occludin and ZO-1 complex, defined by small angle X-ray ... - PNAS
2012年6月18日 · Using small angle X-ray scattering (SAXS), NMR chemical shift perturbation, cross-saturation, in vitro binding, and site-directed mutagenesis experiments. we define the …
The SH3 domain of the tight junction protein ZO-1 binds to a …
1996年12月16日 · We show that the SH3 domain of ZO-1 binds a serine protein kinase that phosphorylates a region immediately C-terminal to the SH3 domain. This kinase associates …
ZO-1/ZONAB信号通路与细胞的增殖分化 - 维普期刊官网
ZONAB结合于ZO-1的SH3 (Src homology 3)结构域,并与多种调控细胞周期的基因、蛋白质、酶、转录因子等相互作用,共同构成ZO-1/ZONAB信号通路。 研究证实,ZO-1/ZONAB信号通路参与 …
Tight junction proteins occludin and ZO-1 as regulators of …
ZO-1 was the first tight junction protein to be discovered. 22 It is a cytosolic peripheral membrane protein with multiple domains specialized for protein interactions. Among these are three PDZ …
Phase Separation of Zonula Occludens Proteins Drives Formation of …
2019年10月31日 · We discovered that ZO proteins self-organize membrane-attached compartments via phase separation. We identified the multivalent interactions of the …
The tight junction protein ZO‐1 and an interacting transcription …
2000年5月2日 · Epithelial tight junctions regulate paracellular diffusion and restrict the intermixing of apical and basolateral plasma membrane components. We now identify a Y‐box …
ZO-1 通过与连接周围细胞骨架的耦合来稳定紧密连接的溶质屏障 …
2009年7月15日 · 通过重新表达全长 ZO-1 或包含 PDZ、SH3 和 GUK 域的 N 端构建体，可以挽救渗透性缺陷以及较小程度的形态学变化。 ZO-2 敲低没有复制 ZO-1 敲低中看到的渗透性或形 …