2024年12月25日 · ZFP57 (ZFP57 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP57 include Diabetes Mellitus, Transient Neonatal, 1 and Transient Neonatal Diabetes Mellitus. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF214.

Zinc finger protein 57 homolog (ZFP57), also known as zinc finger protein 698 (ZNF698), is a protein that in humans is encoded by the ZFP57 gene. [5] The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. [5]

2021年2月4日 · 李夏军课题组之前的研究报道ZFP57是基因组印记的一个关键调控因子，参与维持印记调控区（Imprinting Control Region, ICR）的DNA甲基化印记。 Zfp57是哺乳动物中第一个被发现具有母源-合子效应的基因。

2019年8月9日 · ZFP57 is required to maintain the post-fertilization DNA methylation memory of parental origin at genomic imprints. Here we conduct RNA-seq and ChIP-seq analyses in normal and ZFP57 mutant mouse ES cells to understand the relative importance of ZFP57 at imprints, unique and repetitive regions of the genome.

2021年2月2日 · ZFP57 is a master regulator of genomic imprinting. It has both maternal and zygotic functions that are partially redundant in maintaining DNA methylation at some imprinting control regions (ICRs). In this study, we found that DNA methylation was lost at most known ICRs in Zfp57 mutant embryos …

2011年11月4日 · In this issue of Molecular Cell, Quenneville et al. (2011) characterize the role of ZFP57 in the maintenance of DNA methylation at imprinting control regions (ICRs), revealing an allele-specific binding pattern, binding motif, and interactions with other epigenetic regulators.

Gene ID: 22715, updated on 19-Feb-2025. Enables chromatin binding activity and double-stranded methylated DNA binding activity. Involved in autosome genomic imprinting; epigenetic programing of female pronucleus; and negative regulation of gene expression via chromosomal CpG island methylation.

2025年2月8日 · Study reports mutations in ZFP57, which encodes a zinc-finger transcription factor expressed in early development, in seven pedigrees with a shared pattern of mosaic hypomethylation and a conserved range of clinical features. The protein encoded by this gene is a zinc finger protein containing a KRAB domain.

ZFP57 is an embryonic stem cell-specific transcription factor that is also important in anchorage-independent growth in a fibrosarcoma cell lines. ZFP57 binds to imprinting control region of imprinted genes, one of which is IGF2.

ZFP57 锌指蛋白： 该基因编码的蛋白质是一种含有 KRAB 结构域的锌指蛋白。对小鼠的研究表明，这种蛋白质可能起到转录抑制因子的作用。该基因的突变与 1 型短暂性新生儿糖尿病 (TNDM1) 有关。[RefSeq 提供，2009 年 9 月]