2021年7月13日 · A recent study confirmed the timing of major ZGA, employing the single-cell RNA sequencing (scRNA-seq) method on pig early in vivo fertilized embryos, to dissect the molecular features of ...

2022年11月24日 · Pigs and bovines have the highest coefficient of similarity in biological processes during ZGA. This study provides an important reference for further studying the reprogramming regulatory mechanism of porcine embryos during ZGA.

2025年1月2日 · The zygotic genome activation (ZGA) is crucial for the development of pre-implantation embryos. Long noncoding RNAs (lncRNAs) play significant roles in many biological processes, but the study on their role in the early embryonic development of pigs is limited.

2020年8月10日 · Our data highlight a potential unique 3D chromatin pattern of enriched superdomains in pig preimplantation embryos, an unusual decompartmentalization process during ZGA in the uniparental embryos, and an asynchronized TAD reprogramming between maternal and paternal genomes, implying a severe dysregu …

2024年9月19日 · In pigs, ZGA occurs at the 4-cell (4 C) stage, indicating that correct gene expression at this stage plays an important regulatory role in embryonic development. However, the effect of the HT...

合子基因组的激活通常经历两个阶段，即初级ZGA（minor ZGA，ZGA，zygotic genome activation）与主要ZGA（major ZGA）。 在小鼠早期胚胎发育过程中，初级ZGA起始于在一细胞中晚期，主要转录一小部分基因和一些重复序列。

2020年8月10日 · Our data highlight a potential unique 3D chromatin pattern of enriched superdomains in pig preimplantation embryos, an unusual decompartmentalization process during ZGA in the uniparental embryos, and an asynchronized TAD reprogramming between maternal and paternal genomes, implying a severe dysregulation of …

The zygotic genome activation (ZGA) is crucial for the development of pre-implantation embryos. Long noncoding RNAs (lncRNAs) play significant roles in many biological processes, but the study on their role in the early embryonic development of pigs …

ZGA, employing the single-cell RNA sequencing (scRNA-seq) method on pig early in vivo fertilized embryos, to dissect the molecular features of pluripotency, dynamics of X-chromosome dosage ...

2021年7月13日 · Successful early embryo development requires the correct reprogramming and configuration of gene networks by the timely and faithful execution of zygotic genome activation (ZGA). However, the regulatory principle of molecular elements and circuits fundamental to embryo development remains largely ob …