ZHX2 in health and disease - Frontiers
2022年11月4日 · As a transcriptional factor and the negative regulator of alpha fetal protein (AFP), Zinc fingers and homeoboxes 2 (ZHX2) has a well-established role in protection …
ZHX2 deficiency enriches hybrid MET cells through regulating E
2023年7月17日 · Here, we find that loss of ZHX2 expression results in the hybrid MET phenotype in mesenchymal TNBC cells. Mechanistically, through directly binding to the CDH1 promoter, …
Transcription factor Zhx2 is a checkpoint that programs …
2023年8月15日 · Here, we show that Zhx2 controls macrophage polarization under the inflammatory stimulus and TME. Myeloid-specific deletion of Zhx2 suppresses LPS-induced …
Zinc fingers and homeoboxes 2 is required for ... - PubMed
We previously identified the transcription factor zinc fingers and homeoboxes 2 (Zhx2) as a regulator of hepatic gene expression, and many Zhx2 target genes are dysregulated in HCC. …
马春红教授团队揭示转录因子ZHX2调控巨噬细胞极化及抗肿瘤功 …
2023年8月28日 · 巨噬细胞特异性zhx2基因敲除能够加速小鼠肝癌进程，且巨噬细胞中tgf-β，cd206等表达升高，而cd8+t细胞功能受抑。机制研究发现，zhx2与nf-κb p65蛋白相互结 …
Cell Death Differ丨马春红团队揭示转录因子Zhx2作为调控巨噬细 …
2023年8月31日 · 近日，Cell Death & Differentiation在线发表了山东大学基础医学院马春红团队题为Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and …
ZHX2的研究进展 - 百度学术
新型转录抑制因子ZHX2 (zinc-fingers and homeoboxes 2,ZHX2)属于锌指和同源框 (zinc-fingers and homeoboxes,ZHX)家族,广泛存在于各种组织细胞核内,发挥转录抑制作用.ZHX2与多发性骨 …
ZHX2 in health and disease - PubMed
2022年11月18日 · As a transcriptional factor and the negative regulator of alpha fetal protein (AFP), Zinc fingers and homeoboxes 2 (ZHX2) has a well-established role in protection …
肿瘤抑制因子ZHX2研究进展 - 百度学术
zhx2通过抑制细胞增殖和迁移以及耐药相关基因表达抑制肝细胞肝癌等多种肿瘤的进展.最新研究报道, zhx2通过促进nf-κb激活,促进肾细胞肾癌的发生,强烈提示zhx2在不同肿瘤中发挥不同作用, …
Transcription factor Zhx2 is a checkpoint that programs …
Here, we show that Zhx2 controls macrophage polarization under the inflammatory stimulus and TME. Myeloid-specific deletion of Zhx2 suppresses LPS-induced proinflammatory polarization …