2022年11月4日 · As a transcriptional factor and the negative regulator of alpha fetal protein (AFP), Zinc fingers and homeoboxes 2 (ZHX2) has a well-established role in protection against hepatocellular carcinoma (HCC). However, recent studies have suggested ZHX2 as an oncogene in clear cell renal cell carcinoma (ccRCC) and triple-negative breast cancer (TNBC).

2023年7月17日 · Here, we find that loss of ZHX2 expression results in the hybrid MET phenotype in mesenchymal TNBC cells. Mechanistically, through directly binding to the CDH1 promoter, depletion of ZHX2...

2023年8月15日 · Here, we show that Zhx2 controls macrophage polarization under the inflammatory stimulus and TME. Myeloid-specific deletion of Zhx2 suppresses LPS-induced proinflammatory polarization but...

We previously identified the transcription factor zinc fingers and homeoboxes 2 (Zhx2) as a regulator of hepatic gene expression, and many Zhx2 target genes are dysregulated in HCC. Here, we investigate HCC in Zhx2-deficient mice using …

2023年8月28日 · 巨噬细胞特异性zhx2基因敲除能够加速小鼠肝癌进程，且巨噬细胞中tgf-β，cd206等表达升高，而cd8+t细胞功能受抑。机制研究发现，zhx2与nf-κb p65蛋白相互结合，转录激活irf1表达，上调il-1β、il-6、tnf-α等细胞因子分泌，促进巨噬细胞向促炎表型极化。

2023年8月31日 · 近日，Cell Death & Differentiation在线发表了山东大学基础医学院马春红团队题为Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response 的研究论文。该研究报道了ZHX2在多种环境下调控巨噬细胞极化的重要作用。

新型转录抑制因子ZHX2 (zinc-fingers and homeoboxes 2,ZHX2)属于锌指和同源框 (zinc-fingers and homeoboxes,ZHX)家族,广泛存在于各种组织细胞核内,发挥转录抑制作用.ZHX2与多发性骨髓瘤 (multiple mye-loma,MM)和肝细胞癌 (hepatocellular carcinoma,HCC)的发生发展密切相关.此外,ZHX2对肾脏疾病发展过程中基因表达的转录调控有重要作用.ZHX2亦参与大脑皮层发育过程中神经前体细胞维持的调控. 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析 …

2022年11月18日 · As a transcriptional factor and the negative regulator of alpha fetal protein (AFP), Zinc fingers and homeoboxes 2 (ZHX2) has a well-established role in protection against hepatocellular carcinoma (HCC). However, recent studies have suggested ZHX2 as an oncogene in clear cell renal cell carcinoma (c …

zhx2通过抑制细胞增殖和迁移以及耐药相关基因表达抑制肝细胞肝癌等多种肿瘤的进展.最新研究报道, zhx2通过促进nf-κb激活,促进肾细胞肾癌的发生,强烈提示zhx2在不同肿瘤中发挥不同作用,值得深入研究.另外, zhx2还参与病毒感染,代谢调节,发育及其他多种重要病理 ...

Here, we show that Zhx2 controls macrophage polarization under the inflammatory stimulus and TME. Myeloid-specific deletion of Zhx2 suppresses LPS-induced proinflammatory polarization but promotes IL-4 and TME-induced anti-inflammatory and pro …