用于肺部输送的布地奈德脂质体纳米颗粒的制备及其在 OVA 诱导 …
布地奈德脂质体纳米颗粒 （BUD-LNP） 的开发旨在提高药物的生物利用度，从而提高哮喘治疗的有效性。 方法：通过薄膜水合制备 BUD-LNPs，并研究 BUD-LNPs 的表征、稳定性和体外释放。 通过激光扫描共聚焦显微镜 （LSCM） 和流式细胞术观察体外细胞摄取。 通过测量活化巨噬细胞中促炎细胞因子的表达来评价 BUD-LNPs 的体外抗炎活性。 此外，在体内比较了通过脂质体载体递送的药物和游离药物在肺中的积累时间。 并在 OVA 诱导的哮喘小鼠中评估了 BUD-LNPs …
Preparation of Budesonide-Loaded Liposomal Nanoparticles for …
Budesonide liposomal nanoparticles (BUD-LNPs) were developed to improve the bioavailability of the drug and thereby improve the effectiveness of asthma treatment. BUD-LNPs were prepared via thin-film hydration, and the characterizations, stability, and …
一种有效治疗中性粒细胞性哮喘的新型过氧化氢酶纳米凝 …
2024年4月2日 · 在这项工作中，合成了一种新型的用于递送 CAT (CAT-NGs) 的纳米凝胶，将 CAT 与抗菌“保护膜”结合在一起，作为治疗中性粒细胞性哮喘的一种方式。 与游离CAT相比，CAT-NGs表现出优异的酶活性和胰蛋白酶抗性，并在体外表现出出色的抗炎和抗氧化活性。 此外，CAT-NGs 对不可分型流感嗜血杆菌(NTHi)、金黄色葡萄球菌( S. aureus ) 和大肠杆菌( E. coli ) 表现出显着的抑制作用。 此外，雾化吸入 CAT-NG 可减轻中性粒细胞性哮喘小鼠的肺部炎症 …
Preparation of Budesonide-Loaded Liposomal Nanoparticles for …
BUD-LNPs exhibited excellent biosafety and anti-inflammatory activity in vitro. Furthermore, compared with the free drugs, the utilization of liposomal nano-vehicles for drugs delivery could effectively extend the duration of drugs accumulation in the pulmonary system.
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Yinuo Zhao | IEEE Xplore Author Details
Yinuo Zhao is working toward the MSc degree under the supervision of Prof. Chi Harold Liu in the School of Computer Science and Technology, Beijing Institute of Technology, China. She is now working on the incentive mechanism design for mobile crowdsensing with …
Pressure-sensitive multivesicular liposomes as a smart drug …
In a canine model of acute lung injury continuous HF improved cardiopulmonary function, reduced pulmonary edema, decreased lung permeability and inflammation, and decreased the plasma concentration of proinflammatory cytokines. Journal of controlled release : official journal…
Preparation of Budesonide-Loaded Liposomal Nanoparticles for
2024年1月21日 · Budesonide liposomal nanoparticles (BUD-LNPs) were developed to improve the bioavailability of the drug and thereby improve the effectiveness of asthma treatment. Methods: BUD-LNPs were prepared via thin-film hydration, and the characterizations, stability, and in vitro release of BUD-LNPs were studied.
Yinuo GU | Jilin University, Changchun | JUT | Department of ...
Yinuo GU | Cited by 303 | of Jilin University, Changchun (JUT) | Read 13 publications | Contact Yinuo GU
[PDF] Preparation of Budesonide-Loaded Liposomal Nanoparticles …
2024年1月1日 · Preparation of budesonide-loaded porous PLGA microparticles and their therapeutic efficacy in a murine asthma model. Journal of controlled release : official journal…